Gene transfer-based strategies for heart regeneration

Ischemic heart disease is the leading cause of mortality worldwide. Its most frequent and serious complication is acute myocardial infarction, after which the remaining contractile tissue undergoes a process characterized by myocyte hypertrophy and death of the remaining myocardium, and its progress...

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Detalles Bibliográficos
Autores principales: Crottogini, Alberto, Laguens, Rubén Martín
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2009
Materias:
Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/129072
https://pmr.safisiol.org.ar/archive/id/25
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-129072
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
spellingShingle Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
Crottogini, Alberto
Laguens, Rubén Martín
Gene transfer-based strategies for heart regeneration
topic_facet Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
description Ischemic heart disease is the leading cause of mortality worldwide. Its most frequent and serious complication is acute myocardial infarction, after which the remaining contractile tissue undergoes a process characterized by myocyte hypertrophy and death of the remaining myocardium, and its progressive replacement by fibrosis (Sutton and Sharpe 2000). This process, termed remodeling, eventually leads to left ventricular dilation and heart failure. The extent of remodeling is largely dependent upon infarct size (Lenderink <i>et al.</i> 1995). Small infarcts do not induce significant remodeling. Large ones, contrarily, provoke substantial remodeling and therefore evolve towards contractile failure. This explains why regenerating the contractile tissue, a process named cardiomyogenesis, has become a major objective in biomedical research.
format Articulo
Revision
author Crottogini, Alberto
Laguens, Rubén Martín
author_facet Crottogini, Alberto
Laguens, Rubén Martín
author_sort Crottogini, Alberto
title Gene transfer-based strategies for heart regeneration
title_short Gene transfer-based strategies for heart regeneration
title_full Gene transfer-based strategies for heart regeneration
title_fullStr Gene transfer-based strategies for heart regeneration
title_full_unstemmed Gene transfer-based strategies for heart regeneration
title_sort gene transfer-based strategies for heart regeneration
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/129072
https://pmr.safisiol.org.ar/archive/id/25
work_keys_str_mv AT crottoginialberto genetransferbasedstrategiesforheartregeneration
AT laguensrubenmartin genetransferbasedstrategiesforheartregeneration
bdutipo_str Repositorios
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