Antifouling activity of peracetylated cholic acid, a natural bile acid derivative

The antifouling activity of peracetylated cholic acid (1), a bile acid derivative which was isolated in a previous work as a natural product from the Patagonian sponge Siphonochalina fortis, was evaluated in laboratory and field trials. Toxicity and settlement assays were performed with the mussel M...

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Autores principales:	Pérez, Miriam Cristina, Sánchez, Marianela, García, Mónica Teresita, Patiño C., Laura P., Blustein, Guillermo, Palermo, Jorge Alejandro
Formato:	Articulo Preprint
Lenguaje:	Inglés
Publicado:	2019
Materias:	Química Antifouling activity Acetylated bile acids Marine invertebrates Siphonochalina fortis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/128621
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-128621
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Antifouling activity Acetylated bile acids Marine invertebrates Siphonochalina fortis
spellingShingle	Química Antifouling activity Acetylated bile acids Marine invertebrates Siphonochalina fortis Pérez, Miriam Cristina Sánchez, Marianela García, Mónica Teresita Patiño C., Laura P. Blustein, Guillermo Palermo, Jorge Alejandro Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
topic_facet	Química Antifouling activity Acetylated bile acids Marine invertebrates Siphonochalina fortis
description	The antifouling activity of peracetylated cholic acid (1), a bile acid derivative which was isolated in a previous work as a natural product from the Patagonian sponge Siphonochalina fortis, was evaluated in laboratory and field trials. Toxicity and settlement assays were performed with the mussel Mytilus edulis platensis, while the field trials were carried out by addition of the compound to experimental soluble-matrix paints, which were then tested in the sea. The results obtained in this work show that 1 has a good antifouling activity and low toxicity, and the paints aditivated with 0,6% Wt showed promissory performances in the field trials at the sea. These results confirm the previous hypothesis that the few acetylated and lipophilic bile acid derivatives isolated from marine invertebrates may act as natural antifoulants. Compound 1 is a natural, biodegradable product that can be easily prepared from cholic acid, which in turn can be isolated in industrial scale from cattle bile. All these facts make cholic acid a good scaffold for the preparation of derivatives, which can be natural product-like, effective and sustainable antifouling additives for marine paints and other applications.
format	Articulo Preprint
author	Pérez, Miriam Cristina Sánchez, Marianela García, Mónica Teresita Patiño C., Laura P. Blustein, Guillermo Palermo, Jorge Alejandro
author_facet	Pérez, Miriam Cristina Sánchez, Marianela García, Mónica Teresita Patiño C., Laura P. Blustein, Guillermo Palermo, Jorge Alejandro
author_sort	Pérez, Miriam Cristina
title	Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
title_short	Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
title_full	Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
title_fullStr	Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
title_full_unstemmed	Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
title_sort	antifouling activity of peracetylated cholic acid, a natural bile acid derivative
publishDate	2019
url	http://sedici.unlp.edu.ar/handle/10915/128621
work_keys_str_mv	AT perezmiriamcristina antifoulingactivityofperacetylatedcholicacidanaturalbileacidderivative AT sanchezmarianela antifoulingactivityofperacetylatedcholicacidanaturalbileacidderivative AT garciamonicateresita antifoulingactivityofperacetylatedcholicacidanaturalbileacidderivative AT patinoclaurap antifoulingactivityofperacetylatedcholicacidanaturalbileacidderivative AT blusteinguillermo antifoulingactivityofperacetylatedcholicacidanaturalbileacidderivative AT palermojorgealejandro antifoulingactivityofperacetylatedcholicacidanaturalbileacidderivative
bdutipo_str	Repositorios
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Antifouling activity of peracetylated cholic acid, a natural bile acid derivative

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