Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery

Stereospecific nucleation of mesoporous hybrid microspheres composed of CaCO 3 and carrageenan was appended to one side of bacterial cellulose membrane synthesized in static cultures of Gluconacetobacter hansenii to develop an implantable drug delivery device. The synthesis of the hybrid micropartic...

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Autores principales: Cacicedo, Maximiliano Luis, Cesca, Karina, Bosio, Valeria Elizabeth, Porto, Luismar Marques, Castro, Guillermo Raúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Química
Biología
Self-assembly
Nanocomposites
Hybrid microparticles
Bacterial cellulose
Doxorubicin
Smart chemotherapy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128183
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128183
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Biología
Self-assembly
Nanocomposites
Hybrid microparticles
Bacterial cellulose
Doxorubicin
Smart chemotherapy
spellingShingle Química
Biología
Self-assembly
Nanocomposites
Hybrid microparticles
Bacterial cellulose
Doxorubicin
Smart chemotherapy
Cacicedo, Maximiliano Luis
Cesca, Karina
Bosio, Valeria Elizabeth
Porto, Luismar Marques
Castro, Guillermo Raúl
Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
topic_facet Química
Biología
Self-assembly
Nanocomposites
Hybrid microparticles
Bacterial cellulose
Doxorubicin
Smart chemotherapy
description Stereospecific nucleation of mesoporous hybrid microspheres composed of CaCO 3 and carrageenan was appended to one side of bacterial cellulose membrane synthesized in static cultures of Gluconacetobacter hansenii to develop an implantable drug delivery device. The synthesis of the hybrid microparticles proceeds by self-assembly mechanism in the presence of calcium and contains tailorable amounts of doxorubicin. However, in the absence of the particles, doxorubicin was distributed along the BC film, but without control release of drug. Infrared spectroscopy, confocal and scanning electron microscopies analyses demonstrate that the doxorubicin is entrapped inside the hybrid particles with approximately 80% drug loading compared to the 11% obtained for native bacterial cellulose. Doxorubicin content in the hybrid particles can be increased by a factor of 10 (from 258.6 to 2586.3 nmol ml −1 ), and also by the quantities of particles regulated by the CaCO 3 –carrageenan content and the physicochemical microenvironment. The hybrid BC system can be considered as smart device since the kinetic release of doxorubicin from the hybrid cellulose system rise from 1.50 to 2.75 μg/membrane/day when the pH decreases from 7.4 to 5.8 at 37 °C, a pathologic simulated environment. The hybrid microparticle system can be potentially used as an implantable drug delivery system for personalized oncological therapies.
format Articulo
Articulo
author Cacicedo, Maximiliano Luis
Cesca, Karina
Bosio, Valeria Elizabeth
Porto, Luismar Marques
Castro, Guillermo Raúl
author_facet Cacicedo, Maximiliano Luis
Cesca, Karina
Bosio, Valeria Elizabeth
Porto, Luismar Marques
Castro, Guillermo Raúl
author_sort Cacicedo, Maximiliano Luis
title Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
title_short Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
title_full Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
title_fullStr Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
title_full_unstemmed Self-assembly of carrageenin–CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
title_sort self-assembly of carrageenin–caco3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/128183
work_keys_str_mv AT cacicedomaximilianoluis selfassemblyofcarrageenincaco3hybridmicroparticlesonbacterialcellulosefilmsfordoxorubicinsustaineddelivery
AT cescakarina selfassemblyofcarrageenincaco3hybridmicroparticlesonbacterialcellulosefilmsfordoxorubicinsustaineddelivery
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AT portoluismarmarques selfassemblyofcarrageenincaco3hybridmicroparticlesonbacterialcellulosefilmsfordoxorubicinsustaineddelivery
AT castroguillermoraul selfassemblyofcarrageenincaco3hybridmicroparticlesonbacterialcellulosefilmsfordoxorubicinsustaineddelivery
bdutipo_str Repositorios
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