Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions

Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations w...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Passini, Sabrina Mariela, Montoya, L., Lupi, Martin Pablo, Lorenzini, Paula Mercedes, Landoni, María Fabiana, Albarellos, G. A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128043
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128043
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
spellingShingle Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
Passini, Sabrina Mariela
Montoya, L.
Lupi, Martin Pablo
Lorenzini, Paula Mercedes
Landoni, María Fabiana
Albarellos, G. A.
Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
topic_facet Ciencias Veterinarias
Antimicrobials
Clindamycin
Plasma concentrations
Tissue concentrations
Cats
description Clindamycin plasma and tissue disposition in cats under surgical conditions after a single intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration at a dose rate of 10 mg/kg were studied. After intravenous, intramuscular and subcutaneous administration, peak plasma concentrations were 10.93±3.78 μg/mL (Cp(0)), 5.93±1.18 μg/mL (Cmax)) and 6.30±0.88 μg/mL (Cmax)), respectively. Eight hours after clindamycin IV, IM and SC administration plasma concentrations declined to 2.01±0.61 μg/mL, 2.96±0.43 μg/mL and 3.36±0.97 μg/mL, respectively. Sixty to 90 minutes after clindamycin administration, tissue concentrations ranged from a minimum in subcutaneous tissue of 4.90 μg/g (IV), 3.06 μg/g (IM) and, 3.13 μg/g (SC) to a maximum in uterus of 13.41 μg/g (IV), 14.07 μg/g (IM) and, 14.44 μg/g (SC). The lowest tissue/plasma concentration ratio for the three administration routes was observed in subcutaneous tissue, while the highest was observed at genital level (ovary for IV and IM and uterus for SC). Estimated efficacy predictor (AUC/MIC), considering MIC breakpoint for bacteria isolated from animals, indicates that clindamycin administered IV, IM or SC at the studied dose is appropriated for perioperative prophylactic protocols and that given with a dose interval of 12 hours would be effective for susceptible infection treatment in cats.
format Articulo
Articulo
author Passini, Sabrina Mariela
Montoya, L.
Lupi, Martin Pablo
Lorenzini, Paula Mercedes
Landoni, María Fabiana
Albarellos, G. A.
author_facet Passini, Sabrina Mariela
Montoya, L.
Lupi, Martin Pablo
Lorenzini, Paula Mercedes
Landoni, María Fabiana
Albarellos, G. A.
author_sort Passini, Sabrina Mariela
title Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_short Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_full Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_fullStr Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_full_unstemmed Plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
title_sort plasma and tissue clindamycin antimicrobial activity after parenteral administration to cats under surgical conditions
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/128043
work_keys_str_mv AT passinisabrinamariela plasmaandtissueclindamycinantimicrobialactivityafterparenteraladministrationtocatsundersurgicalconditions
AT montoyal plasmaandtissueclindamycinantimicrobialactivityafterparenteraladministrationtocatsundersurgicalconditions
AT lupimartinpablo plasmaandtissueclindamycinantimicrobialactivityafterparenteraladministrationtocatsundersurgicalconditions
AT lorenzinipaulamercedes plasmaandtissueclindamycinantimicrobialactivityafterparenteraladministrationtocatsundersurgicalconditions
AT landonimariafabiana plasmaandtissueclindamycinantimicrobialactivityafterparenteraladministrationtocatsundersurgicalconditions
AT albarellosga plasmaandtissueclindamycinantimicrobialactivityafterparenteraladministrationtocatsundersurgicalconditions
bdutipo_str Repositorios
_version_ 1764820451755819009

Ejemplares similares