Magnetic field-assisted gene delivery: achievements and therapeutic potential

The discovery in the early 2000’s that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to...

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Autores principales:	Schwerdt, José Ignacio, Goya, Gerardo F., Calatayud, M. Pilar, Hereñú, Claudia Beatriz, Reggiani, Paula Cecilia, Goya, Rodolfo Gustavo
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/127940
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-127940
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine
spellingShingle	Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine Schwerdt, José Ignacio Goya, Gerardo F. Calatayud, M. Pilar Hereñú, Claudia Beatriz Reggiani, Paula Cecilia Goya, Rodolfo Gustavo Magnetic field-assisted gene delivery: achievements and therapeutic potential
topic_facet	Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine
description	The discovery in the early 2000’s that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strategies for a number of major pathologies like cancer, neurodegeneration and myocardial infarction. The goal of MDT is to concentrate MNPs functionalized with therapeutic drugs, in target areas of the body by means of properly focused external magnetic fields. The availability of stable, nontoxic MNP-gene vector complexes now offers the opportunity to develop magnetic gene targeting (MGT), a variant of MDT in which the gene coding for a therapeutic molecule, rather than the molecule itself, is delivered to a therapeutic target area in the body. This article will first outline the principle of magnetofection, subsequently describing the properties of the magnetic fields and MNPs used in this technique. Next, it will review the results achieved by magnetofection in cell cultures. Last, the potential of MGT for implementing minimally invasive gene therapy will be discussed.
format	Articulo Articulo
author	Schwerdt, José Ignacio Goya, Gerardo F. Calatayud, M. Pilar Hereñú, Claudia Beatriz Reggiani, Paula Cecilia Goya, Rodolfo Gustavo
author_facet	Schwerdt, José Ignacio Goya, Gerardo F. Calatayud, M. Pilar Hereñú, Claudia Beatriz Reggiani, Paula Cecilia Goya, Rodolfo Gustavo
author_sort	Schwerdt, José Ignacio
title	Magnetic field-assisted gene delivery: achievements and therapeutic potential
title_short	Magnetic field-assisted gene delivery: achievements and therapeutic potential
title_full	Magnetic field-assisted gene delivery: achievements and therapeutic potential
title_fullStr	Magnetic field-assisted gene delivery: achievements and therapeutic potential
title_full_unstemmed	Magnetic field-assisted gene delivery: achievements and therapeutic potential
title_sort	magnetic field-assisted gene delivery: achievements and therapeutic potential
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/127940
work_keys_str_mv	AT schwerdtjoseignacio magneticfieldassistedgenedeliveryachievementsandtherapeuticpotential AT goyagerardof magneticfieldassistedgenedeliveryachievementsandtherapeuticpotential AT calatayudmpilar magneticfieldassistedgenedeliveryachievementsandtherapeuticpotential AT herenuclaudiabeatriz magneticfieldassistedgenedeliveryachievementsandtherapeuticpotential AT reggianipaulacecilia magneticfieldassistedgenedeliveryachievementsandtherapeuticpotential AT goyarodolfogustavo magneticfieldassistedgenedeliveryachievementsandtherapeuticpotential
bdutipo_str	Repositorios
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Magnetic field-assisted gene delivery: achievements and therapeutic potential

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