Physiological role of hormone ouabain
Ouabain, a substance obtained from plant extracts, has been long known as cardiotonic, as well as by its high affinity to the Na-K- ATPase pump. The recent finding that ouabain is endogenously expressed in mammals has prompted research to determine its role as a hormone. We have shown that, in a phy...
| Autores principales: | , , , , |
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| Formato: | Articulo Revision |
| Lenguaje: | Inglés |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/127779 https://pmr.safisiol.org.ar/archive/id/78 |
| Aporte de: |
| id |
I19-R120-10915-127779 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer |
| spellingShingle |
Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer Cereijido, M. Ponce, A. Larre, M. I. Castillo, A. Hinojosa, L. Physiological role of hormone ouabain |
| topic_facet |
Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer |
| description |
Ouabain, a substance obtained from plant extracts, has been long known as cardiotonic, as well as by its high affinity to the Na-K- ATPase pump. The recent finding that ouabain is endogenously expressed in mammals has prompted research to determine its role as a hormone. We have shown that, in a physiological level (10 nM), it influences on three important features of epithelial physiology related to cell to cell contacts: (1) It modifies the Tight Junction integrity, as reflected by an increase in the Transepithelial Electrical Resistance (TER) of mature monolayers of MDCK cells. (2) It speeds up ciliogenesis, a feature closely related to epithelial (Apical/Basolateral) polarity and (3) It triggers Gap Junctional Intercellular Communication (GJIC). Since lack of GJIC has been associated to cancer, ouabain may be an interesting player on this issue. |
| format |
Articulo Revision |
| author |
Cereijido, M. Ponce, A. Larre, M. I. Castillo, A. Hinojosa, L. |
| author_facet |
Cereijido, M. Ponce, A. Larre, M. I. Castillo, A. Hinojosa, L. |
| author_sort |
Cereijido, M. |
| title |
Physiological role of hormone ouabain |
| title_short |
Physiological role of hormone ouabain |
| title_full |
Physiological role of hormone ouabain |
| title_fullStr |
Physiological role of hormone ouabain |
| title_full_unstemmed |
Physiological role of hormone ouabain |
| title_sort |
physiological role of hormone ouabain |
| publishDate |
2015 |
| url |
http://sedici.unlp.edu.ar/handle/10915/127779 https://pmr.safisiol.org.ar/archive/id/78 |
| work_keys_str_mv |
AT cereijidom physiologicalroleofhormoneouabain AT poncea physiologicalroleofhormoneouabain AT larremi physiologicalroleofhormoneouabain AT castilloa physiologicalroleofhormoneouabain AT hinojosal physiologicalroleofhormoneouabain |
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Repositorios |
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