A general theory to explain heart rate and cardiac contractility changes with advancing age

Sinus node dysfunction and chronic heart failure have been, and will continue to be , major health issue issues in humans for the foreseeable future future. The heartbeat originateoriginates from spontaneously firing sinoatrial nodal (SAN) pacemaker cells. A coupledcoupled-clock system underlies the...

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Detalles Bibliográficos
Autores principales:	Tsutsui, Kenta, Monfredi, Oliver J., Lakatta, Edward G.
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Médicas Aging Sinoatrial node Pacemaker cell Phosphorylation Coupled-clock system General theory
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/127649 https://pmr.safisiol.org.ar/archive/id/83
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-127649
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Aging Sinoatrial node Pacemaker cell Phosphorylation Coupled-clock system General theory
spellingShingle	Ciencias Médicas Aging Sinoatrial node Pacemaker cell Phosphorylation Coupled-clock system General theory Tsutsui, Kenta Monfredi, Oliver J. Lakatta, Edward G. A general theory to explain heart rate and cardiac contractility changes with advancing age
topic_facet	Ciencias Médicas Aging Sinoatrial node Pacemaker cell Phosphorylation Coupled-clock system General theory
description	Sinus node dysfunction and chronic heart failure have been, and will continue to be , major health issue issues in humans for the foreseeable future future. The heartbeat originateoriginates from spontaneously firing sinoatrial nodal (SAN) pacemaker cells. A coupledcoupled-clock system underlies the robust and flexible automaticity in these cells cells. The basal action potential (AP) firing rate of SAN cells is largely determined by the degree of phosphorylation o of critical proteins in th the coupledcoupled-clock system. Autonomic neuronal signaling from the brain effects changes in AP firing rate via modulatmodulation of cAMP and cAMP cAMP-mediated PKAPKA-dependent phosphorylationphosphorylation. Age -associated alterationalterations in intrinsic SAN cell behavior and associated changes in brainbrain-heart communication play cent ral role roles in the development of SAN cell pacemaker failure. This minimini-review provides integrated insights into the molecular mechanisms underlying the effects of aging on deterioration in beating rate and contractility of the heart in animal models and in apparently healthy humans.
format	Articulo Revision
author	Tsutsui, Kenta Monfredi, Oliver J. Lakatta, Edward G.
author_facet	Tsutsui, Kenta Monfredi, Oliver J. Lakatta, Edward G.
author_sort	Tsutsui, Kenta
title	A general theory to explain heart rate and cardiac contractility changes with advancing age
title_short	A general theory to explain heart rate and cardiac contractility changes with advancing age
title_full	A general theory to explain heart rate and cardiac contractility changes with advancing age
title_fullStr	A general theory to explain heart rate and cardiac contractility changes with advancing age
title_full_unstemmed	A general theory to explain heart rate and cardiac contractility changes with advancing age
title_sort	general theory to explain heart rate and cardiac contractility changes with advancing age
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/127649 https://pmr.safisiol.org.ar/archive/id/83
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A general theory to explain heart rate and cardiac contractility changes with advancing age

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