Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability

Assembly and stabilization of a glutathione-complexed [2Fe–2S] cluster is promoted by aggregation of glutathione. The cluster core selects the tetramer species from a collection of equilibrating solution aggregate species, and in turn the core is stabilized toward hydrolytic degradation. Studies of...

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Detalles Bibliográficos
Autores principales: Qi, Wenbin, Li, Jingwei, Chain, Cecilia Yamil, Pasquevich, Gustavo Alberto, Pasquevich, Alberto Felipe, Cowan, J. A.
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2013
Materias:
Química
Reaction intermediate
Cluster (physics)
Mass spectrometry
Chemistry
Combinatorial chemistry
Tetramer
Molecule
Sulfur
Glutathione
Crystallography
Turn (biochemistry)
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127388
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127388
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Reaction intermediate
Cluster (physics)
Mass spectrometry
Chemistry
Combinatorial chemistry
Tetramer
Molecule
Sulfur
Glutathione
Crystallography
Turn (biochemistry)
spellingShingle Química
Reaction intermediate
Cluster (physics)
Mass spectrometry
Chemistry
Combinatorial chemistry
Tetramer
Molecule
Sulfur
Glutathione
Crystallography
Turn (biochemistry)
Qi, Wenbin
Li, Jingwei
Chain, Cecilia Yamil
Pasquevich, Gustavo Alberto
Pasquevich, Alberto Felipe
Cowan, J. A.
Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
topic_facet Química
Reaction intermediate
Cluster (physics)
Mass spectrometry
Chemistry
Combinatorial chemistry
Tetramer
Molecule
Sulfur
Glutathione
Crystallography
Turn (biochemistry)
description Assembly and stabilization of a glutathione-complexed [2Fe–2S] cluster is promoted by aggregation of glutathione. The cluster core selects the tetramer species from a collection of equilibrating solution aggregate species, and in turn the core is stabilized toward hydrolytic degradation. Studies of glutathione derivatives, in combination with mass spectrometric and Mossbauer investigations provide insight on reaction intermediates during formation of [2Fe–2S](GS)₄²⁻.
format Articulo
Preprint
author Qi, Wenbin
Li, Jingwei
Chain, Cecilia Yamil
Pasquevich, Gustavo Alberto
Pasquevich, Alberto Felipe
Cowan, J. A.
author_facet Qi, Wenbin
Li, Jingwei
Chain, Cecilia Yamil
Pasquevich, Gustavo Alberto
Pasquevich, Alberto Felipe
Cowan, J. A.
author_sort Qi, Wenbin
title Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
title_short Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
title_full Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
title_fullStr Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
title_full_unstemmed Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
title_sort glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/127388
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