Gene therapy for the treatment of pituitary tumors
Pituitary adenomas constitute the most frequent neuroendocrine pathology in humans. Current therapies include surgery, radiotherapy and pharmacological approaches. Although useful, none of them offers a permanent cure. Current research efforts to implement gene therapy in pituitary tumors include th...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/127128 |
| Aporte de: |
| id |
I19-R120-10915-127128 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Gene therapy Viral vectors Pituitary tumors IGF-I gene therapy Neurosurgery Suicide gene therapy Proapoptotic genes Combined therapy |
| spellingShingle |
Ciencias Médicas Gene therapy Viral vectors Pituitary tumors IGF-I gene therapy Neurosurgery Suicide gene therapy Proapoptotic genes Combined therapy Rodríguez, Silvia Susana Castro, María Graciela Brown, Oscar Alfredo Goya, Rodolfo Gustavo Cónsole-Avegliano, Gloria Miriam Gene therapy for the treatment of pituitary tumors |
| topic_facet |
Ciencias Médicas Gene therapy Viral vectors Pituitary tumors IGF-I gene therapy Neurosurgery Suicide gene therapy Proapoptotic genes Combined therapy |
| description |
Pituitary adenomas constitute the most frequent neuroendocrine pathology in humans. Current therapies include surgery, radiotherapy and pharmacological approaches. Although useful, none of them offers a permanent cure. Current research efforts to implement gene therapy in pituitary tumors include the treatment of experimental adenomas with adenoviral vector-mediated transfer of the suicide gene for thymidine kinase, which converts the prodrug ganciclovir into a toxic metabolite. In some cases, the suicide transgene has been placed under the control of pituitary cell-type specific promoters. Also, regulatable adenoviral vector systems are being assessed in gene therapy approaches for experimental pituitary tumors. Although the efficiency and safety of current viral vectors must be optimized before clinical use, they remain as highly promising therapeutic tools. |
| format |
Articulo Preprint |
| author |
Rodríguez, Silvia Susana Castro, María Graciela Brown, Oscar Alfredo Goya, Rodolfo Gustavo Cónsole-Avegliano, Gloria Miriam |
| author_facet |
Rodríguez, Silvia Susana Castro, María Graciela Brown, Oscar Alfredo Goya, Rodolfo Gustavo Cónsole-Avegliano, Gloria Miriam |
| author_sort |
Rodríguez, Silvia Susana |
| title |
Gene therapy for the treatment of pituitary tumors |
| title_short |
Gene therapy for the treatment of pituitary tumors |
| title_full |
Gene therapy for the treatment of pituitary tumors |
| title_fullStr |
Gene therapy for the treatment of pituitary tumors |
| title_full_unstemmed |
Gene therapy for the treatment of pituitary tumors |
| title_sort |
gene therapy for the treatment of pituitary tumors |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/127128 |
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AT rodriguezsilviasusana genetherapyforthetreatmentofpituitarytumors AT castromariagraciela genetherapyforthetreatmentofpituitarytumors AT brownoscaralfredo genetherapyforthetreatmentofpituitarytumors AT goyarodolfogustavo genetherapyforthetreatmentofpituitarytumors AT consoleaveglianogloriamiriam genetherapyforthetreatmentofpituitarytumors |
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Repositorios |
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1764820451311222784 |