The role of primary cilia in cancer

Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types o...

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Detalles Bibliográficos
Autores principales: Peixoto, Estanislao, Mansini, Adrian P., Thelen, Kristen M., Gaspari, Cesar I., Jin, Sujeong, Gradilone, Sergio A.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2017
Materias:
Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125649
https://pmr.safisiol.org.ar/archive/id/93
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125649
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
spellingShingle Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
Peixoto, Estanislao
Mansini, Adrian P.
Thelen, Kristen M.
Gaspari, Cesar I.
Jin, Sujeong
Gradilone, Sergio A.
The role of primary cilia in cancer
topic_facet Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
description Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.
format Articulo
Revision
author Peixoto, Estanislao
Mansini, Adrian P.
Thelen, Kristen M.
Gaspari, Cesar I.
Jin, Sujeong
Gradilone, Sergio A.
author_facet Peixoto, Estanislao
Mansini, Adrian P.
Thelen, Kristen M.
Gaspari, Cesar I.
Jin, Sujeong
Gradilone, Sergio A.
author_sort Peixoto, Estanislao
title The role of primary cilia in cancer
title_short The role of primary cilia in cancer
title_full The role of primary cilia in cancer
title_fullStr The role of primary cilia in cancer
title_full_unstemmed The role of primary cilia in cancer
title_sort role of primary cilia in cancer
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/125649
https://pmr.safisiol.org.ar/archive/id/93
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