Neutrophil extracellular traps (NETS): role in disease

Neutrophil extracellular traps (NETs) are web-like structures composed by a chromatin backbone, histones and antimicrobial proteins. NETs constitute yet another mechanism deployed by neutrophils to immobilise and kill microorganisms, thus contributing to the host innate immunity. Neutrophils cast NE...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Garciarena, Carolina Denis, Kerrigan, Steve W.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
Neutrophil extracellular traps
Histones
Sepsis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125645
https://pmr.safisiol.org.ar/archive/id/97
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125645
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Neutrophil extracellular traps
Histones
Sepsis
spellingShingle Ciencias Médicas
Neutrophil extracellular traps
Histones
Sepsis
Garciarena, Carolina Denis
Kerrigan, Steve W.
Neutrophil extracellular traps (NETS): role in disease
topic_facet Ciencias Médicas
Neutrophil extracellular traps
Histones
Sepsis
description Neutrophil extracellular traps (NETs) are web-like structures composed by a chromatin backbone, histones and antimicrobial proteins. NETs constitute yet another mechanism deployed by neutrophils to immobilise and kill microorganisms, thus contributing to the host innate immunity. Neutrophils cast NETs upon stimulation by a variety of stimuli, including bacteria, protozoa, fungi, viruses, their products and also host factors like chemokines, complement and activated platelets. NETs production or NETosis occurs as a result of activation of neutrophil PKC, Raf-MEK-ERK and NADPH oxydase signalling pathways. Driven mostly by peptidylarginine deiminase 4 (PAD4) citrullination of histones, the hallmark of NETosis is chromatin decondensation, rupture of nuclear membrane and release of nuclear and granular contents into the cytoplasm, prior their release into the extracellular space. NETs control propagation of pathogens by entrapping them within the lose chromatin web and kills them with the antimicrobial molecules –granule proteins and histones- present in high concentrations within the chromatin network. Despite contributing to host defence, aberrant NET formation may damage tissues and activate inflammatory cells, contributing to several pathologies, including sepsis, systemic inflammatory response syndrome, autoimmune diseases and thrombosis. This review presents an overview of our current knowledge of NETs physiology and their role in fighting and propagating disease.
format Articulo
Revision
author Garciarena, Carolina Denis
Kerrigan, Steve W.
author_facet Garciarena, Carolina Denis
Kerrigan, Steve W.
author_sort Garciarena, Carolina Denis
title Neutrophil extracellular traps (NETS): role in disease
title_short Neutrophil extracellular traps (NETS): role in disease
title_full Neutrophil extracellular traps (NETS): role in disease
title_fullStr Neutrophil extracellular traps (NETS): role in disease
title_full_unstemmed Neutrophil extracellular traps (NETS): role in disease
title_sort neutrophil extracellular traps (nets): role in disease
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/125645
https://pmr.safisiol.org.ar/archive/id/97
work_keys_str_mv AT garciarenacarolinadenis neutrophilextracellulartrapsnetsroleindisease
AT kerriganstevew neutrophilextracellulartrapsnetsroleindisease
bdutipo_str Repositorios
_version_ 1764820451980214273

Ejemplares similares