Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia
Background Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19, and preliminary evidence shows that it might have beneficial effect. Our objective was to compare epidemiological characteristics and outcomes between patients who...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
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2020
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/125340 |
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I19-R120-10915-125340 |
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dspace |
| institution |
Universidad Nacional de La Plata |
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I-19 |
| repository_str |
R-120 |
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SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Epidemiology Internal medicine Retrospective cohort study Adverse effect Expanded access Intensive care unit Mechanical ventilation Pneumonia Medicine Cohort Covid 19 |
| spellingShingle |
Ciencias Médicas Epidemiology Internal medicine Retrospective cohort study Adverse effect Expanded access Intensive care unit Mechanical ventilation Pneumonia Medicine Cohort Covid 19 Salazar, Martín R. González, Soledad E. Regairaz, Lorena Ferrando, Noelia González Martínez, Veronica V. Carrera Ramos, Patricia M. Muñoz, Laura Pesci, Santiago A. Vidal, Juan M. Kreplak, Nicolás Estenssoro, Elisa Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia |
| topic_facet |
Ciencias Médicas Epidemiology Internal medicine Retrospective cohort study Adverse effect Expanded access Intensive care unit Mechanical ventilation Pneumonia Medicine Cohort Covid 19 |
| description |
Background Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19, and preliminary evidence shows that it might have beneficial effect. Our objective was to compare epidemiological characteristics and outcomes between patients who received convalescent plasma for COVID-19 and those who did not, admitted to hospitals in Buenos Aires Province, Argentina, throughout the pandemic. Methods This is a multicenter, retrospective cohort study of 2-month duration beginning on June 1, 2020, including unselected, consecutive adult patients with diagnosed COVID-19, admitted to 215 hospitals with pneumonia. Epidemiological and clinical variables were registered in the Provincial Hospital Bed Management System. Convalescent plasma was supplied as part of a centralized, expanded access program.
Results We analyzed 3,529 patients with pneumonia, predominantly male, aged 62±17, with arterial hypertension and diabetes as main comorbidities; 51.4% were admitted to the ward, 27.1% to the Intensive Care Unit (ICU), and 21.7% to the ICU with mechanical ventilation requirement (ICU-MV). 28-day mortality was 34.9%; and was 26.3%, 30.1% and 61.4% for ward, ICU and ICU-MV patients. Convalescent plasma was administered to 868 patients (24.6%); their 28-day mortality was significantly lower (25.5% vs. 38.0%, p Logistic regression analysis identified age, ICU admission with and without MV requirement, diabetes and preexistent cardiovascular disease as independent predictors of 28-day mortality, whereas convalescent plasma administration acted as a protective factor.
Conclusions Our study suggests that the administration of convalescent plasma in COVID-19 pneumonia admitted to the hospital might be associated with decreased mortality. Key Points Preliminary evidence showed that convalescent plasma might be beneficial in COVID-19. In a cohort of 3,529 patients with pneumonia due to COVID-19, convalescent plasma was administered to 868 patients, without major adverse effects. Convalescent plasma was independently associated with decreased mortality. |
| format |
Articulo Preprint |
| author |
Salazar, Martín R. González, Soledad E. Regairaz, Lorena Ferrando, Noelia González Martínez, Veronica V. Carrera Ramos, Patricia M. Muñoz, Laura Pesci, Santiago A. Vidal, Juan M. Kreplak, Nicolás Estenssoro, Elisa |
| author_facet |
Salazar, Martín R. González, Soledad E. Regairaz, Lorena Ferrando, Noelia González Martínez, Veronica V. Carrera Ramos, Patricia M. Muñoz, Laura Pesci, Santiago A. Vidal, Juan M. Kreplak, Nicolás Estenssoro, Elisa |
| author_sort |
Salazar, Martín R. |
| title |
Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia |
| title_short |
Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia |
| title_full |
Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia |
| title_fullStr |
Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia |
| title_full_unstemmed |
Effect of convalescent plasma on mortality in patients with Covid-19 pneumonia |
| title_sort |
effect of convalescent plasma on mortality in patients with covid-19 pneumonia |
| publishDate |
2020 |
| url |
http://sedici.unlp.edu.ar/handle/10915/125340 |
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