Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia

Convalescent plasma administration (CPA) is widely used to treat Covid-19, but its effectiveness remains controversial. Here we report the results of an Expanded Access Program of CPA in the province of Buenos Aires, Argentina. We evaluated the relationship between the timing of CPA and 28-day morta...

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Detalles Bibliográficos
Autores principales: González, Soledad E., Regairaz, Lorena, Salazar, Martín R., Ferrando, Noelia Soledad, Gonzalez Martínez, Verónica, Ramos, P. Carrera, Pesci, Santiago A., Vidal, Juan M., Kreplak, Nicolás, Estenssoro, Elisa
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
Covid-19 pneumonia
Plasma convalescent
Outcome
28-day mortality
Early administration
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125182
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125182
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Covid-19 pneumonia
Plasma convalescent
Outcome
28-day mortality
Early administration
spellingShingle Ciencias Médicas
Covid-19 pneumonia
Plasma convalescent
Outcome
28-day mortality
Early administration
González, Soledad E.
Regairaz, Lorena
Salazar, Martín R.
Ferrando, Noelia Soledad
Gonzalez Martínez, Verónica
Ramos, P. Carrera
Pesci, Santiago A.
Vidal, Juan M.
Kreplak, Nicolás
Estenssoro, Elisa
Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia
topic_facet Ciencias Médicas
Covid-19 pneumonia
Plasma convalescent
Outcome
28-day mortality
Early administration
description Convalescent plasma administration (CPA) is widely used to treat Covid-19, but its effectiveness remains controversial. Here we report the results of an Expanded Access Program of CPA in the province of Buenos Aires, Argentina. We evaluated the relationship between the timing of CPA and 28-day mortality in 4719 hospitalized patients with COVID-19 pneumonia. Early ([≤]3 days from admission) CPA was associated to decreased mortality in patients in the general ward and in the Intensive Care Unit not requiring mechanical ventilation. This suggests that the favorable effect of CPA might be related both to disease acuity and to the therapeutic window.
format Articulo
Preprint
author González, Soledad E.
Regairaz, Lorena
Salazar, Martín R.
Ferrando, Noelia Soledad
Gonzalez Martínez, Verónica
Ramos, P. Carrera
Pesci, Santiago A.
Vidal, Juan M.
Kreplak, Nicolás
Estenssoro, Elisa
author_facet González, Soledad E.
Regairaz, Lorena
Salazar, Martín R.
Ferrando, Noelia Soledad
Gonzalez Martínez, Verónica
Ramos, P. Carrera
Pesci, Santiago A.
Vidal, Juan M.
Kreplak, Nicolás
Estenssoro, Elisa
author_sort González, Soledad E.
title Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia
title_short Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia
title_full Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia
title_fullStr Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia
title_full_unstemmed Timing of Convalescent plasma administration and 28-day mortality for COVID-19 pneumonia
title_sort timing of convalescent plasma administration and 28-day mortality for covid-19 pneumonia
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/125182
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