Environmental pollutant hexachlorobenzene induces hypertension in a rat model

Hexachlorobenzene (HCB) is a dioxin-like environmental pollutant, widely distributed in the environment. New research links exposure to high levels of persistent organic environmental toxicants to cardiovascular disease, however little is known about the effect of HCB on vascular function and on blo...

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Autores principales: Castilla, Rocío, Asuaje, Agustín, Rivière, Stéphanie, Romero, Caimi Giselle, Martín, Pedro, Cao, Gabriel, de Pisarev, Diana Kleiman, Milesi, María Verónica, Álvarez, Laura
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
Materias:
Biología
Hexachlorobenzene
Hypertension
Aorta
TGF-β1
ERα
Deiodinase II
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124979
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124979
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Hexachlorobenzene
Hypertension
Aorta
TGF-β1
ERα
Deiodinase II
spellingShingle Biología
Hexachlorobenzene
Hypertension
Aorta
TGF-β1
ERα
Deiodinase II
Castilla, Rocío
Asuaje, Agustín
Rivière, Stéphanie
Romero, Caimi Giselle
Martín, Pedro
Cao, Gabriel
de Pisarev, Diana Kleiman
Milesi, María Verónica
Álvarez, Laura
Environmental pollutant hexachlorobenzene induces hypertension in a rat model
topic_facet Biología
Hexachlorobenzene
Hypertension
Aorta
TGF-β1
ERα
Deiodinase II
description Hexachlorobenzene (HCB) is a dioxin-like environmental pollutant, widely distributed in the environment. New research links exposure to high levels of persistent organic environmental toxicants to cardiovascular disease, however little is known about the effect of HCB on vascular function and on blood pressure. The purpose of the present study was to evaluate biochemical and cardiovascular changes resulting from subchronic HCB exposure. Adult female Sprague-Dawley rats were treated with vehicle or HCB (5 or 500 mg/kg b.w) for 45 days. Systolic blood pressure (BP), recorded by tail cuff plethysmography, was significantly increased at 35, 40 and 45 days of 500 mg/kg HCB-treatment. HCB (500 mg/kg) increased arterial thickness, while both 5 and 500 mg/kg HCB decreased proliferating cell nuclear antigen (PCNA) protein levels and cellular nuclei in abdominal aortas indicating a hypertrophic process. Also, aortas from both groups of HCB-treated rats presented higher sensitivity to noradrenalin (NA) and a significant decrease in maximum contractile response. Arteries from 500 mg/kg HCB-treated rats showed a significant increase in the levels of transforming growth factor-β1 (TGF-β1) mRNA and angiotensin II type1 receptor (AT1), and a significant decrease in estrogen receptor alpha (ERα), endothelial nitric oxidide synthase (eNOS) protein expression and deiodinase II (DII) mRNA levels. In conclusion, we have demonstrated for the first time that subchronic HCB administration significantly increases BP and alters associated cardiovascular parameters in rats. In addition, HCB alters the expression of key vascular tissue molecules involved in BP regulation, such as TGF-β1, AT1, ERα, eNOS and DII.
format Articulo
Preprint
author Castilla, Rocío
Asuaje, Agustín
Rivière, Stéphanie
Romero, Caimi Giselle
Martín, Pedro
Cao, Gabriel
de Pisarev, Diana Kleiman
Milesi, María Verónica
Álvarez, Laura
author_facet Castilla, Rocío
Asuaje, Agustín
Rivière, Stéphanie
Romero, Caimi Giselle
Martín, Pedro
Cao, Gabriel
de Pisarev, Diana Kleiman
Milesi, María Verónica
Álvarez, Laura
author_sort Castilla, Rocío
title Environmental pollutant hexachlorobenzene induces hypertension in a rat model
title_short Environmental pollutant hexachlorobenzene induces hypertension in a rat model
title_full Environmental pollutant hexachlorobenzene induces hypertension in a rat model
title_fullStr Environmental pollutant hexachlorobenzene induces hypertension in a rat model
title_full_unstemmed Environmental pollutant hexachlorobenzene induces hypertension in a rat model
title_sort environmental pollutant hexachlorobenzene induces hypertension in a rat model
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/124979
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