Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee

The aim of this work was to evaluate antimicrobial activity against <i>Paenibacillus larvae</i> and oral toxicity against workers and larvae of <i>Apis mellifera</i> of gallic acid (GA) and two nanohybrids of GA and silica. Also, the physicochemical, structural, and energetic...

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Detalles Bibliográficos
Autores principales: Domínguez, Enzo, Moliné, María P., Churio, María Sandra, Arce, Valeria Beatriz, Mártire, Daniel Osvaldo, Álvarez, Brenda S., Gende, Liesel Brenda, Damiani, Natalia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124801
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124801
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
spellingShingle Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
Domínguez, Enzo
Moliné, María P.
Churio, María Sandra
Arce, Valeria Beatriz
Mártire, Daniel Osvaldo
Álvarez, Brenda S.
Gende, Liesel Brenda
Damiani, Natalia
Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
topic_facet Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
description The aim of this work was to evaluate antimicrobial activity against <i>Paenibacillus larvae</i> and oral toxicity against workers and larvae of <i>Apis mellifera</i> of gallic acid (GA) and two nanohybrids of GA and silica. Also, the physicochemical, structural, and energetic properties of GA and the nanohybrids were determined through structure–activity relationship (SAR). The minimum inhibitory concentration (MIC) against <i>P. larvae</i> was determined. GA showed MIC values between 62.5 and 125 μg/ml, whereas the nanoparticle functionalized through the GA carboxylic moiety (NP2) showed the best antimicrobial activity with a MIC value of 23 μg GA/ml for four of the five isolates used. SAR analysis showed that electronegativity, chemical hardness, and dipolar moment are reliable estimators of the antimicrobial activity. NP2 showed the lowest toxicity against workers and was innocuous for bee larvae. Therefore, the nanohybrid NP2 was the best antibacterial and resulted in non-toxic against workers and larvae of honeybees, becoming a potentially effective and safe agent for the treatment of American Foulbrood disease.
format Articulo
Articulo
author Domínguez, Enzo
Moliné, María P.
Churio, María Sandra
Arce, Valeria Beatriz
Mártire, Daniel Osvaldo
Álvarez, Brenda S.
Gende, Liesel Brenda
Damiani, Natalia
author_facet Domínguez, Enzo
Moliné, María P.
Churio, María Sandra
Arce, Valeria Beatriz
Mártire, Daniel Osvaldo
Álvarez, Brenda S.
Gende, Liesel Brenda
Damiani, Natalia
author_sort Domínguez, Enzo
title Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_short Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_full Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_fullStr Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_full_unstemmed Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_sort bioactivity of gallic acid–conjugated silica nanoparticles against <i>paenibacillus larvae</i> and their host, <i>apis mellifera</i> honeybee
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/124801
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