Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors

In humans, affective states can bias responses to ambiguous information: a phenomenon termed judgment bias (JB). Judgment biases have great potential for assessing affective states in animals, in both animal welfare and biomedical research. New animal JB tasks require construct validation, but for l...

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Detalles Bibliográficos
Autores principales: Resasco, Agustina, MacLellan, Aileen, Ayala, Miguel Ángel, Kitchenham, Lindsey, Edwards, M., Lam, S., Dejardin, S., Mason, Georgia
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Veterinarias
Veterinaria
Laboratory mice
Judgment bias
Validation
Affective state
Animal welfare
Cáncer
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124715
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124715
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Veterinaria
Laboratory mice
Judgment bias
Validation
Affective state
Animal welfare
Cáncer
spellingShingle Ciencias Veterinarias
Veterinaria
Laboratory mice
Judgment bias
Validation
Affective state
Animal welfare
Cáncer
Resasco, Agustina
MacLellan, Aileen
Ayala, Miguel Ángel
Kitchenham, Lindsey
Edwards, M.
Lam, S.
Dejardin, S.
Mason, Georgia
Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors
topic_facet Ciencias Veterinarias
Veterinaria
Laboratory mice
Judgment bias
Validation
Affective state
Animal welfare
Cáncer
description In humans, affective states can bias responses to ambiguous information: a phenomenon termed judgment bias (JB). Judgment biases have great potential for assessing affective states in animals, in both animal welfare and biomedical research. New animal JB tasks require construct validation, but for laboratory mice (Mus musculus), the most common research vertebrate, a valid JB task has proved elusive. Here (Experiment 1), we demonstrate construct validity for a novel mouse JB test: an olfactory Go/Go task in which subjects dig for high- or low-value food rewards. In C57BL/6 and Balb/c mice faced with ambiguous cues, latencies to dig were sensitive to high/low welfare housing, environmentally-enriched animals responding with relative ‘optimism’ through shorter latencies. Illustrating the versatility of a validated JB task across fields of research, it further allowed us to test hypotheses about the mood-altering effects of cancer (Experiment 2). Male nude mice bearing subcutaneous lung adenocarcinomas responded more pessimistically than healthy controls to ambiguous cues. Similar effects were not seen in females, however. To our knowledge, this is the first validation of a mouse JB task and the first demonstration of pessimism in tumor-bearing animals. This task, especially if refined to improve its sensitivity, thus has great potential for investigating mouse welfare, the links between affective state and disease, depression-like states in animals, and hypotheses regarding the neurobiological mechanisms that underlie affect-mediated biases in judgment.
format Articulo
Preprint
author Resasco, Agustina
MacLellan, Aileen
Ayala, Miguel Ángel
Kitchenham, Lindsey
Edwards, M.
Lam, S.
Dejardin, S.
Mason, Georgia
author_facet Resasco, Agustina
MacLellan, Aileen
Ayala, Miguel Ángel
Kitchenham, Lindsey
Edwards, M.
Lam, S.
Dejardin, S.
Mason, Georgia
author_sort Resasco, Agustina
title Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors
title_short Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors
title_full Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors
title_fullStr Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors
title_full_unstemmed Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors
title_sort cancer blues? a validated judgment bias task suggests pessimism in nude mice with tumors
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/124715
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