Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
Polyamine-salt aggregates (PSA) are biomimetic soft materials that have attracted great attention due to their straightforward fabrication methods, high drug-loading efficiencies, and attractive properties for pH-triggered release. Herein, a simple and fast multicomponent self-assembly process was u...
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Formato: | Articulo |
Lenguaje: | Inglés |
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2020
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/124628 |
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I19-R120-10915-124628 |
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Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
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SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Exactas Química drug delivery molecular recognition nanostructures self-assembly supramolecular chemistry |
spellingShingle |
Ciencias Exactas Química drug delivery molecular recognition nanostructures self-assembly supramolecular chemistry Agazzi, Maximiliano Luis Herrera, Santiago Esteban Cortez, María Lorena Marmisollé, Waldemar Alejandro Azzaroni, Omar Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy |
topic_facet |
Ciencias Exactas Química drug delivery molecular recognition nanostructures self-assembly supramolecular chemistry |
description |
Polyamine-salt aggregates (PSA) are biomimetic soft materials that have attracted great attention due to their straightforward fabrication methods, high drug-loading efficiencies, and attractive properties for pH-triggered release. Herein, a simple and fast multicomponent self-assembly process was used to construct cross-linked poly(allylamine hydrochloride)/phosphate PSAs (hydrodynamic diameter of 360 nm) containing glucose oxidase enzyme, as a glucose-responsive element, and human recombinant insulin, as a therapeutic agent for the treatment of diabetes mellitus (GI-PSA). The addition of increasing glucose concentrations promotes the release of insulin due to the disassembly of the GI-PSAs triggered by the catalytic in situ formation of gluconic acid. Under normoglycemia, the GI-PSA integrity remained intact for at least 24 h, whereas hyperglycemic conditions resulted in 100 % cargo release after 4 h of glucose addition. This entirely supramolecular strategy presents great potential for the construction of smart glucose-responsive delivery nanocarriers. |
format |
Articulo Articulo |
author |
Agazzi, Maximiliano Luis Herrera, Santiago Esteban Cortez, María Lorena Marmisollé, Waldemar Alejandro Azzaroni, Omar |
author_facet |
Agazzi, Maximiliano Luis Herrera, Santiago Esteban Cortez, María Lorena Marmisollé, Waldemar Alejandro Azzaroni, Omar |
author_sort |
Agazzi, Maximiliano Luis |
title |
Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy |
title_short |
Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy |
title_full |
Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy |
title_fullStr |
Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy |
title_full_unstemmed |
Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy |
title_sort |
insulin delivery from glucose-responsive, self-assembled, polyamine nanoparticles: smart "sense-and-treat" nanocarriers made easy |
publishDate |
2020 |
url |
http://sedici.unlp.edu.ar/handle/10915/124628 |
work_keys_str_mv |
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bdutipo_str |
Repositorios |
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1764820450765963267 |