Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery

The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techni...

Descripción completa

Detalles Bibliográficos
Autores principales: Chain, Cecilia Yamil, Daza Millone, María Antonieta, Cisneros, José Sebastián, Ramírez, Eduardo Alejandro, Vela, María Elena
Formato: Articulo
Lenguaje:Español
Publicado: 2021
Materias:
Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124237
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124237
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
spellingShingle Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
Chain, Cecilia Yamil
Daza Millone, María Antonieta
Cisneros, José Sebastián
Ramírez, Eduardo Alejandro
Vela, María Elena
Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
topic_facet Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
description The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis.
format Articulo
Articulo
author Chain, Cecilia Yamil
Daza Millone, María Antonieta
Cisneros, José Sebastián
Ramírez, Eduardo Alejandro
Vela, María Elena
author_facet Chain, Cecilia Yamil
Daza Millone, María Antonieta
Cisneros, José Sebastián
Ramírez, Eduardo Alejandro
Vela, María Elena
author_sort Chain, Cecilia Yamil
title Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_short Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_full Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_fullStr Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_full_unstemmed Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_sort surface plasmon resonance as a characterization tool for lipid nanoparticles used in drug delivery
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/124237
work_keys_str_mv AT chainceciliayamil surfaceplasmonresonanceasacharacterizationtoolforlipidnanoparticlesusedindrugdelivery
AT dazamillonemariaantonieta surfaceplasmonresonanceasacharacterizationtoolforlipidnanoparticlesusedindrugdelivery
AT cisnerosjosesebastian surfaceplasmonresonanceasacharacterizationtoolforlipidnanoparticlesusedindrugdelivery
AT ramirezeduardoalejandro surfaceplasmonresonanceasacharacterizationtoolforlipidnanoparticlesusedindrugdelivery
AT velamariaelena surfaceplasmonresonanceasacharacterizationtoolforlipidnanoparticlesusedindrugdelivery
bdutipo_str Repositorios
_version_ 1764820449984774147

Ejemplares similares