Evaluation of antioxidant activity of emulsan <i>in vitro</i>
Oxidative stress has been involved in the development of several pathologies, including vascular damage associated to myocardial and neurological degeneration, such as arteriosclerosis, cerebral ischemia among others; while diabetes, rheumatoid arthritis, inflammation, cancer-initiation, and acceler...
Guardado en:
| Autores principales: | , , , , , , , |
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| Formato: | Libro Capitulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Asiatech Publishers
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/123854 https://www.researchgate.net/publication/232769182_Evaluation_of_antioxidant_activity_of_emulsan_in_vitro |
| Aporte de: |
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I19-R120-10915-123854 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Química Estrés Oxidativo Oxígeno reactivo Especies de Nitrógeno Reactivo |
| spellingShingle |
Química Estrés Oxidativo Oxígeno reactivo Especies de Nitrógeno Reactivo Castro, Guillermo Raúl Zuluaga, Natalia Panilaitis, Bruce Kaplan, David Pandey, A. Larroche, C. Soccol, C. R. Dussap, C.-G. Evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| topic_facet |
Química Estrés Oxidativo Oxígeno reactivo Especies de Nitrógeno Reactivo |
| description |
Oxidative stress has been involved in the development of several pathologies, including vascular damage associated to myocardial and neurological degeneration, such as arteriosclerosis, cerebral ischemia among others; while diabetes, rheumatoid arthritis, inflammation, cancer-initiation, and acceleration of the aging processes are also reported (Coyle and Puttfarcken, 1993; Margail et al., 2005). The toxicity of oxidative stress is believed to be caused by Reactive Oxygen and Nitrogen Species (ROS and RNS, respectively) that can initiate a wide range of oxidative toxic reactions in biological systems (Cuzzocrea et al., 2001). Typical radicals and radical-related toxic molecules produced by ROS are hydrogen peroxide (H2O2), hydroxyl radical (OH⋅), singlet oxygen (1O2), and superoxide anion radical (O2 ⋅-) (Figure 1). The RNS toxic reactants include nitric oxide (NO⋅) and the most powerful oxidant peroxynitrite anion (ONOO-). Biological antioxidant mechanisms described in the literature are many, but with different efficiencies implicating enzymatic as well as non-enzymatic activities. Some of the most relevant antioxidative biocatalysts are superoxide dismutase, and catalase. In addition, other specialized enzymes such as glutathione peroxidase and ã-glutamylcysteine synthetase can be involved in deactivation mechanisms (Figure 1). Well-known non-enzymatic antioxidants are b-carotene, glutathione, melatonin and vitamins C and E, (Valko et al., 2006). However, excessive and persistent formation of free radicals could be main factors of genotoxic effects. |
| format |
Libro Capitulo de libro |
| author |
Castro, Guillermo Raúl Zuluaga, Natalia Panilaitis, Bruce Kaplan, David Pandey, A. Larroche, C. Soccol, C. R. Dussap, C.-G. |
| author_facet |
Castro, Guillermo Raúl Zuluaga, Natalia Panilaitis, Bruce Kaplan, David Pandey, A. Larroche, C. Soccol, C. R. Dussap, C.-G. |
| author_sort |
Castro, Guillermo Raúl |
| title |
Evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| title_short |
Evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| title_full |
Evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| title_fullStr |
Evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| title_full_unstemmed |
Evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| title_sort |
evaluation of antioxidant activity of emulsan <i>in vitro</i> |
| publisher |
Asiatech Publishers |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/123854 https://www.researchgate.net/publication/232769182_Evaluation_of_antioxidant_activity_of_emulsan_in_vitro |
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Repositorios |
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