Effect of epinephrine on the oxidative desaturation of fatty acids in the rat

The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-l...

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Autores principales:	Tacconi de Gómez Dumm, Irma Nelva, Tacconi de Alaniz, María Josefa, Brenner, Rodolfo Roberto
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	1976
Materias:	Ciencias Médicas Palmitic acid Linoleic acid alpha-linolenic acid Glucose metabolism Liver microsomes Cyclic AMP
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/123448
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-123448
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Palmitic acid Linoleic acid alpha-linolenic acid Glucose metabolism Liver microsomes Cyclic AMP
spellingShingle	Ciencias Médicas Palmitic acid Linoleic acid alpha-linolenic acid Glucose metabolism Liver microsomes Cyclic AMP Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
topic_facet	Ciencias Médicas Palmitic acid Linoleic acid alpha-linolenic acid Glucose metabolism Liver microsomes Cyclic AMP
description	The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-linolenic acid to octadeca- 6,9,12,15-tetraenoic acid 12 hr after the injection. Lower doses produced a lesser effect on the A6-desaturation activity. Epinephrine administration modified the V,,, of linoleic acid desaturation but not the K,. There was also a slight increase in palmityl desaturation activity. The ef- fect of epinephrine on A6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit A6-desaturation activity.
format	Articulo Articulo
author	Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto
author_facet	Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto
author_sort	Tacconi de Gómez Dumm, Irma Nelva
title	Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_short	Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_full	Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_fullStr	Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_full_unstemmed	Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
title_sort	effect of epinephrine on the oxidative desaturation of fatty acids in the rat
publishDate	1976
url	http://sedici.unlp.edu.ar/handle/10915/123448
work_keys_str_mv	AT tacconidegomezdummirmanelva effectofepinephrineontheoxidativedesaturationoffattyacidsintherat AT tacconidealanizmariajosefa effectofepinephrineontheoxidativedesaturationoffattyacidsintherat AT brennerrodolforoberto effectofepinephrineontheoxidativedesaturationoffattyacidsintherat
bdutipo_str	Repositorios
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Effect of epinephrine on the oxidative desaturation of fatty acids in the rat

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