Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study

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The frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chr...

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Detalles Bibliográficos
Autores principales: Larramendy, Marcelo Luis, Majander, Päivi, Saarto, Tiina, Tenhunen, Mikko, Caballín, Rosa, Elomaa, Inkeri, Knuutila, Sakari
Formato: Articulo
Lenguaje:Inglés
Publicado: 1998
Materias:
Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/122867
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-122867
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
spellingShingle Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
Larramendy, Marcelo Luis
Majander, Päivi
Saarto, Tiina
Tenhunen, Mikko
Caballín, Rosa
Elomaa, Inkeri
Knuutila, Sakari
Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
topic_facet Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
description The frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples.
format Articulo
Articulo
author Larramendy, Marcelo Luis
Majander, Päivi
Saarto, Tiina
Tenhunen, Mikko
Caballín, Rosa
Elomaa, Inkeri
Knuutila, Sakari
author_facet Larramendy, Marcelo Luis
Majander, Päivi
Saarto, Tiina
Tenhunen, Mikko
Caballín, Rosa
Elomaa, Inkeri
Knuutila, Sakari
author_sort Larramendy, Marcelo Luis
title Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_short Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_full Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_fullStr Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_full_unstemmed Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_sort radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
publishDate 1998
url http://sedici.unlp.edu.ar/handle/10915/122867
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bdutipo_str Repositorios
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