Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR

The effect of sub-chronic exposure of intraperitoneal (i.p.) injections of microcystin-LR (MC-LR) on microscopic tissue architecture, hepatic function and lipid peroxidation has been studied in liver and kidney of mice. Mice were treated i.p. with 25 mg of pure MC-LR/kg body weight or saline solutio...

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Autores principales: Andrinolo, Darío, Sedan, Daniela Yazmine, Telese, Luis Horacio, Aura, Claudia, Masera, Silvia, Giannuzzi, Leda, Marra, Carlos Alberto, Tacconi de Alaniz, María Josefa
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Química
Microcystins
Sub-chronic exposure liver recovery
Lipid peroxidation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/114951
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-114951
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Microcystins
Sub-chronic exposure liver recovery
Lipid peroxidation
spellingShingle Química
Microcystins
Sub-chronic exposure liver recovery
Lipid peroxidation
Andrinolo, Darío
Sedan, Daniela Yazmine
Telese, Luis Horacio
Aura, Claudia
Masera, Silvia
Giannuzzi, Leda
Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
topic_facet Química
Microcystins
Sub-chronic exposure liver recovery
Lipid peroxidation
description The effect of sub-chronic exposure of intraperitoneal (i.p.) injections of microcystin-LR (MC-LR) on microscopic tissue architecture, hepatic function and lipid peroxidation has been studied in liver and kidney of mice. Mice were treated i.p. with 25 mg of pure MC-LR/kg body weight or saline solution for 1 month (every 2 days) with the aim of producing an inflictive stage with evident damage. Histopathological analysis of dissected livers of mice showed a disrupted lobar architecture and the development of cytoplasmatic vacuoles. According to this, a significant increase in hepatic lipid content and in lipid peroxidation levels in liver and kidney was found in MC-LR-treated animals when compared with controls. Moreover, serum alkaline phosphatase and aspartate aminotransferase activities showed a significant alteration in MC-LR-treated animals. After damage, progression or recovery was studied for 1 and 2 months of wash-out. The recovery from liver damage was evident at the cytological and physiological level, only the recovery of lobar architecture was incomplete along the period investigated. In conclusion, the present study demonstrates the ability of hepatic tissue to recover from damage produced by sub-chronic MC-LR administration. The dynamic interplay between damage and tissue-repairing response in determining the ultimate outcome of toxicity should be considered in risk-assessment studies.
format Articulo
Articulo
author Andrinolo, Darío
Sedan, Daniela Yazmine
Telese, Luis Horacio
Aura, Claudia
Masera, Silvia
Giannuzzi, Leda
Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
author_facet Andrinolo, Darío
Sedan, Daniela Yazmine
Telese, Luis Horacio
Aura, Claudia
Masera, Silvia
Giannuzzi, Leda
Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
author_sort Andrinolo, Darío
title Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
title_short Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
title_full Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
title_fullStr Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
title_full_unstemmed Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
title_sort hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin lr
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/114951
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