Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials

Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions. Currently, 15 members of this family have been described in mammals, each with its structural and ligand re...

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Detalles Bibliográficos
Autores principales: Compagno, Daniel, Tiraboschi, Carolina, Garcia, José Daniel, Rondón, Yorfer, Corapi, Enrique, Velazquez, Carla, Laderach, Diego José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Farmacia
Ciencias Exactas
Galectins
Carbohydrates
Galectin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107847
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7277089&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107847
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Ciencias Exactas
Galectins
Carbohydrates
Galectin
spellingShingle Farmacia
Ciencias Exactas
Galectins
Carbohydrates
Galectin
Compagno, Daniel
Tiraboschi, Carolina
Garcia, José Daniel
Rondón, Yorfer
Corapi, Enrique
Velazquez, Carla
Laderach, Diego José
Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials
topic_facet Farmacia
Ciencias Exactas
Galectins
Carbohydrates
Galectin
description Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions. Currently, 15 members of this family have been described in mammals, each with its structural and ligand recognition particularities. The galectin/ligand interaction translates into a plethora of biological functions that are particular for each cell/tissue type. In this sense, the cells of the immune system are highly sensitive to the action of these small and essential proteins. While galectins play central roles in tumor progression, they are also excellent negative regulators (checkpoints) of the immune cell functions, participating in the creation of a microenvironment that promotes tumor escape. This review aims to give an updated view on how galectins control the tumor’s immune attack depending on the tumor microenvironment, because determining which galectins are essential and the role they play will help to develop future clinical trials and benefit patients with incurable cancer.
format Articulo
Articulo
author Compagno, Daniel
Tiraboschi, Carolina
Garcia, José Daniel
Rondón, Yorfer
Corapi, Enrique
Velazquez, Carla
Laderach, Diego José
author_facet Compagno, Daniel
Tiraboschi, Carolina
Garcia, José Daniel
Rondón, Yorfer
Corapi, Enrique
Velazquez, Carla
Laderach, Diego José
author_sort Compagno, Daniel
title Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials
title_short Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials
title_full Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials
title_fullStr Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials
title_full_unstemmed Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials
title_sort galectins as checkpoints of the immune system in cancers, their clinical relevance, and implication in clinical trials
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/107847
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7277089&blobtype=pdf
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bdutipo_str Repositorios
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