Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model

Objective: To determine whether adalimumab administration before mechanical ventilation reduces ventilator- -induced lung injury (VILI). Methods: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volu...

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Autores principales: Correger, Enrique, Marcos, Josefina, Laguens, Graciela, Stringa, Pablo Luis, Cardinal Fernández, Pablo, Blanch, Lluis
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Médicas
Adalimumab/administration & dosage
Respiration, artificial
Respiratory failure
Ventilator-induced lung injury
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107778
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7206963&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107778
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Adalimumab/administration & dosage
Respiration, artificial
Respiratory failure
Ventilator-induced lung injury
spellingShingle Ciencias Médicas
Adalimumab/administration & dosage
Respiration, artificial
Respiratory failure
Ventilator-induced lung injury
Correger, Enrique
Marcos, Josefina
Laguens, Graciela
Stringa, Pablo Luis
Cardinal Fernández, Pablo
Blanch, Lluis
Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
topic_facet Ciencias Médicas
Adalimumab/administration & dosage
Respiration, artificial
Respiratory failure
Ventilator-induced lung injury
description Objective: To determine whether adalimumab administration before mechanical ventilation reduces ventilator- -induced lung injury (VILI). Methods: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volume group (n = 6), where tidal volume = 8mL/kg and positive end-expiratory pressure = 5cmH2O; a high tidal volume group (n = 6), where tidal volume = 35mL/kg and positive end-expiratory pressure = 0; and a pretreated + high tidal volume group (n = 6) where adalimumab (100ug/kg) was administered intraperitoneally 24 hours before mechanical ventilation + tidal volume = 35mL/ kg and positive end-expiratory pressure = 0. ANOVA was used to compare histological damage (ATS 2010 Lung Injury Scoring System), pulmonary edema, lung compliance, arterial partial pressure of oxygen, and mean arterial pressure among the groups. Results: After 3 hours of ventilation, the mean histological lung injury score was higher in the high tidal volume group than in the low tidal volume group (0.030 versus 0.0051, respectively, p = 0.003). The high tidal volume group showed diminished lung compliance at 3 hours (p = 0.04) and hypoxemia (p = 0,018 versus control). Pretreated HVt group had an improved histological score, mainly due to a significant reduction in leukocyte infiltration (p = 0.003). Conclusion: Histological examination after 3 hours of injurious ventilation revealed ventilator-induced lung injury in the absence of measurable changes in lung mechanics or oxygenation; administering adalimumab before mechanical ventilation reduced lung edema and histological damage.
format Articulo
Articulo
author Correger, Enrique
Marcos, Josefina
Laguens, Graciela
Stringa, Pablo Luis
Cardinal Fernández, Pablo
Blanch, Lluis
author_facet Correger, Enrique
Marcos, Josefina
Laguens, Graciela
Stringa, Pablo Luis
Cardinal Fernández, Pablo
Blanch, Lluis
author_sort Correger, Enrique
title Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
title_short Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
title_full Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
title_fullStr Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
title_full_unstemmed Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
title_sort pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/107778
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7206963&blobtype=pdf
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