Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overc...

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Autores principales: Chindamo, Giulia, Sapino, Simona, Peira, Elena, Chirio, Daniela, González, Mónica Cristina, Gallarate, Marina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Química
Bone diseases
Bone regeneration. Nanotechnology
Targeted delivery systems
Calcium phosphate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107166
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7279399&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107166
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Bone diseases
Bone regeneration. Nanotechnology
Targeted delivery systems
Calcium phosphate
spellingShingle Química
Bone diseases
Bone regeneration. Nanotechnology
Targeted delivery systems
Calcium phosphate
Chindamo, Giulia
Sapino, Simona
Peira, Elena
Chirio, Daniela
González, Mónica Cristina
Gallarate, Marina
Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
topic_facet Química
Bone diseases
Bone regeneration. Nanotechnology
Targeted delivery systems
Calcium phosphate
description Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.
format Articulo
Articulo
author Chindamo, Giulia
Sapino, Simona
Peira, Elena
Chirio, Daniela
González, Mónica Cristina
Gallarate, Marina
author_facet Chindamo, Giulia
Sapino, Simona
Peira, Elena
Chirio, Daniela
González, Mónica Cristina
Gallarate, Marina
author_sort Chindamo, Giulia
title Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
title_short Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
title_full Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
title_fullStr Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
title_full_unstemmed Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
title_sort bone diseases: current approach and future perspectives in drug delivery systems for bone targeted therapeutics
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/107166
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7279399&blobtype=pdf
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