Data from: Mosquitoes cloak their legs to resist insecticides

Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 20...

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Autores principales:	Balabanidou, Vasileia, Kefi, Mary, Aivaliotis, Michalis, Koidou, Venetia, Girotti, Juan Roberto, Mijailovsky, Sergio Javier, Juárez, Marta Patricia, Papadogiorgaki, Eva, Chalepakis, George, Kampouraki, Anastasia, Nikolaou, Christoforos, Ranson, Hilary, Vontas, John
Formato:	Conjunto de datos
Lenguaje:	Español
Publicado:	2020
Materias:	Ciencias Médicas https://purl.org/becyt/ford/1 insecticide resistance cuticle alterations legs
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/106939 https://rs.figshare.com/collections/Supplementary_material_from_Mosquitoes_cloak_their_legs_to_resist_insecticides_/4566284
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-106939
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spelling	I19-R120-10915-1069392023-04-27T15:09:32Z http://sedici.unlp.edu.ar/handle/10915/106939 https://rs.figshare.com/collections/Supplementary_material_from_Mosquitoes_cloak_their_legs_to_resist_insecticides_/4566284 Data from: Mosquitoes cloak their legs to resist insecticides Balabanidou, Vasileia Kefi, Mary Aivaliotis, Michalis Koidou, Venetia Girotti, Juan Roberto Mijailovsky, Sergio Javier Juárez, Marta Patricia Papadogiorgaki, Eva Chalepakis, George Kampouraki, Anastasia Nikolaou, Christoforos Ranson, Hilary Vontas, John 2020-10-14T16:01:58Z 2019 es Ciencias Médicas https://purl.org/becyt/ford/1 insecticide resistance cuticle alterations legs Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype. Fil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Fil: Girotti, Juan Roberto. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Fil: Juárez, Marta Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner";Argentina Fil: Juárez, Marta Patricia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Fil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Fil: Mijailovsky, Sergio Javier. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Instituto de Investigaciones Bioquímicas de La Plata Conjunto de datos Conjunto de datos http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Español
topic	Ciencias Médicas https://purl.org/becyt/ford/1 insecticide resistance cuticle alterations legs
spellingShingle	Ciencias Médicas https://purl.org/becyt/ford/1 insecticide resistance cuticle alterations legs Balabanidou, Vasileia Kefi, Mary Aivaliotis, Michalis Koidou, Venetia Girotti, Juan Roberto Mijailovsky, Sergio Javier Juárez, Marta Patricia Papadogiorgaki, Eva Chalepakis, George Kampouraki, Anastasia Nikolaou, Christoforos Ranson, Hilary Vontas, John Data from: Mosquitoes cloak their legs to resist insecticides
topic_facet	Ciencias Médicas https://purl.org/becyt/ford/1 insecticide resistance cuticle alterations legs
description	Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
format	Conjunto de datos Conjunto de datos
author	Balabanidou, Vasileia Kefi, Mary Aivaliotis, Michalis Koidou, Venetia Girotti, Juan Roberto Mijailovsky, Sergio Javier Juárez, Marta Patricia Papadogiorgaki, Eva Chalepakis, George Kampouraki, Anastasia Nikolaou, Christoforos Ranson, Hilary Vontas, John
author_facet	Balabanidou, Vasileia Kefi, Mary Aivaliotis, Michalis Koidou, Venetia Girotti, Juan Roberto Mijailovsky, Sergio Javier Juárez, Marta Patricia Papadogiorgaki, Eva Chalepakis, George Kampouraki, Anastasia Nikolaou, Christoforos Ranson, Hilary Vontas, John
author_sort	Balabanidou, Vasileia
title	Data from: Mosquitoes cloak their legs to resist insecticides
title_short	Data from: Mosquitoes cloak their legs to resist insecticides
title_full	Data from: Mosquitoes cloak their legs to resist insecticides
title_fullStr	Data from: Mosquitoes cloak their legs to resist insecticides
title_full_unstemmed	Data from: Mosquitoes cloak their legs to resist insecticides
title_sort	data from: mosquitoes cloak their legs to resist insecticides
publishDate	2020
url	http://sedici.unlp.edu.ar/handle/10915/106939 https://rs.figshare.com/collections/Supplementary_material_from_Mosquitoes_cloak_their_legs_to_resist_insecticides_/4566284
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Data from: Mosquitoes cloak their legs to resist insecticides

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