Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin

Gastropod Molluscs rely exclusively on the innate immune system to protect from pathogens, defending their embryos through maternally transferred effectors. In this regard, Pomacea snail eggs, in addition to immune defenses, have evolved the perivitellin-2 or PV2 combining two immune proteins into a...

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Detalles Bibliográficos
Autores principales: Giglio, Matías Leonel, Ituarte, Santiago, Ibáñez, Andrés Esteban, Dreon, Marcos Sebastián, Prieto, Eduardo Daniel, Fernández, Patricia Elena, Heras, Horacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Química
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/106881
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7082926&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-106881
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
spellingShingle Química
Giglio, Matías Leonel
Ituarte, Santiago
Ibáñez, Andrés Esteban
Dreon, Marcos Sebastián
Prieto, Eduardo Daniel
Fernández, Patricia Elena
Heras, Horacio
Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
topic_facet Química
description Gastropod Molluscs rely exclusively on the innate immune system to protect from pathogens, defending their embryos through maternally transferred effectors. In this regard, Pomacea snail eggs, in addition to immune defenses, have evolved the perivitellin-2 or PV2 combining two immune proteins into a neurotoxin: a lectin and a pore-forming protein from the Membrane Attack Complex/Perforin (MACPF) family. This binary structure resembles AB-toxins, a group of toxins otherwise restricted to bacteria and plants. Many of these are enterotoxins, leading us to explore this activity in PV2. Enterotoxins found in bacteria and plants act mainly as pore-forming toxins and toxic lectins, respectively. In animals, although both pore-forming proteins and lectins are ubiquitous, no enterotoxins have been reported. Considering that Pomacea snail eggs ingestion induce morpho-physiological changes in the intestinal mucosa of rodents and is cytotoxic to intestinal cells in culture, we seek for the factor causing these effects and identified PmPV2 from Pomacea maculata eggs. We characterized the enterotoxic activity of PmPV2 through in vitro and in vivo assays.
format Articulo
Articulo
author Giglio, Matías Leonel
Ituarte, Santiago
Ibáñez, Andrés Esteban
Dreon, Marcos Sebastián
Prieto, Eduardo Daniel
Fernández, Patricia Elena
Heras, Horacio
author_facet Giglio, Matías Leonel
Ituarte, Santiago
Ibáñez, Andrés Esteban
Dreon, Marcos Sebastián
Prieto, Eduardo Daniel
Fernández, Patricia Elena
Heras, Horacio
author_sort Giglio, Matías Leonel
title Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
title_short Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
title_full Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
title_fullStr Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
title_full_unstemmed Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
title_sort novel role for animal innate immune molecules: enterotoxic activity of a snail egg macpf-toxin
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/106881
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7082926&blobtype=pdf
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bdutipo_str Repositorios
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