Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited

To allow the control of their intracellular pH (pHi) and bicarbonate (HCO3 - ) levels, cells express HCO3 - transport proteins (NBC) that rapidly and selectively move HCO3 - across the plasma membrane. In the heart electroneutral NBCn1 and electrogenic NBCe1 Na+ /HCO3 - cotransporters facilitate...

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Detalles Bibliográficos
Autores principales: Álvarez, Bernardo Víctor, Aiello, Ernesto Alejandro
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Médicas
NBC/CA complex
Metabolon
Heart
Bicarbonate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104654
http://hdl.handle.net/11336/60867
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104654
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
NBC/CA complex
Metabolon
Heart
Bicarbonate
spellingShingle Ciencias Médicas
NBC/CA complex
Metabolon
Heart
Bicarbonate
Álvarez, Bernardo Víctor
Aiello, Ernesto Alejandro
Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited
topic_facet Ciencias Médicas
NBC/CA complex
Metabolon
Heart
Bicarbonate
description To allow the control of their intracellular pH (pHi) and bicarbonate (HCO3 - ) levels, cells express HCO3 - transport proteins (NBC) that rapidly and selectively move HCO3 - across the plasma membrane. In the heart electroneutral NBCn1 and electrogenic NBCe1 Na+ /HCO3 - cotransporters facilitate the transmembrane movement of HCO3 - ions into cardiomyocytes, as a response to acid loading. NBCe1 associates with carbonic anhydrases (CA), the enzymes that catalyze the reversible conversion of CO2 to HCO3 - , to form a transport metabolon, a weakly associated complex of sequential metabolic enzymes. NBCe1 physically/functionally interact with the isoforms II, IV, and IX of CA, to increase the HCO3 - flux through cell membranes. NBCe1 and CAs interaction occurs in different cellular compartments in the heart muscle. Physiologically, the NBCe1/CA complex could contribute to the removal of H+ ions accumulated as the result of the contractile activity of the cardiac muscle cell, and this process may occur at the surface sarcolemma (CAII-NBCe1-CAIV complex) or at the ttubule (CAII-NBCe1-CAIX complex) of the cardiomyocyte. Pathologically, upregulation of the NBCe1/CA metabolon system upon ischemic/hypoxic conditions of the heart would favor the hypertrophic growth of the cardiac cells.
format Articulo
Articulo
author Álvarez, Bernardo Víctor
Aiello, Ernesto Alejandro
author_facet Álvarez, Bernardo Víctor
Aiello, Ernesto Alejandro
author_sort Álvarez, Bernardo Víctor
title Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited
title_short Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited
title_full Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited
title_fullStr Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited
title_full_unstemmed Physical and functional interaction of carbonic anhydrases and nbce1 Na+/HCO3- cotransporter in the heart : The metabolon revisited
title_sort physical and functional interaction of carbonic anhydrases and nbce1 na+/hco3- cotransporter in the heart : the metabolon revisited
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/104654
http://hdl.handle.net/11336/60867
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AT aielloernestoalejandro physicalandfunctionalinteractionofcarbonicanhydrasesandnbce1nahco3cotransporterintheheartthemetabolonrevisited
bdutipo_str Repositorios
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