Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a...
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Autores principales: | , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2010
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/104650 http://hdl.handle.net/11336/61840 |
Aporte de: |
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I19-R120-10915-104650 |
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dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Médicas Phospholamban Cardiac relaxation Contractility |
spellingShingle |
Ciencias Médicas Phospholamban Cardiac relaxation Contractility Mattiazzi, Alicia Ramona Mundiña-Weilenmann, Cecilia Vittone, Leticia Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
topic_facet |
Ciencias Médicas Phospholamban Cardiac relaxation Contractility |
description |
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed. |
format |
Articulo Articulo |
author |
Mattiazzi, Alicia Ramona Mundiña-Weilenmann, Cecilia Vittone, Leticia |
author_facet |
Mattiazzi, Alicia Ramona Mundiña-Weilenmann, Cecilia Vittone, Leticia |
author_sort |
Mattiazzi, Alicia Ramona |
title |
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
title_short |
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
title_full |
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
title_fullStr |
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
title_full_unstemmed |
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
title_sort |
phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility |
publishDate |
2010 |
url |
http://sedici.unlp.edu.ar/handle/10915/104650 http://hdl.handle.net/11336/61840 |
work_keys_str_mv |
AT mattiazzialiciaramona phospholambanatinyproteinwithaprominentroleintheregulationofcardiacrelaxationandcontractility AT mundinaweilenmanncecilia phospholambanatinyproteinwithaprominentroleintheregulationofcardiacrelaxationandcontractility AT vittoneleticia phospholambanatinyproteinwithaprominentroleintheregulationofcardiacrelaxationandcontractility |
bdutipo_str |
Repositorios |
_version_ |
1764820442146668545 |