Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice

We analyzed VEGF expression in regenerating liver (after partial hepatectomy) of tumor-bearing adult and young mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h, from 26 to 46 h post-hepatectomy. Liver samples were processed for immunohistochemistry. The results sh...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fernández Blanco, Ayelén, Andrini, Laura Beatriz, Errecalde, Ana Lía, Inda, Ana María, García, Marcela Nilda
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/103324
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-103324
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
spellingShingle Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
Fernández Blanco, Ayelén
Andrini, Laura Beatriz
Errecalde, Ana Lía
Inda, Ana María
García, Marcela Nilda
Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
topic_facet Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
description We analyzed VEGF expression in regenerating liver (after partial hepatectomy) of tumor-bearing adult and young mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h, from 26 to 46 h post-hepatectomy. Liver samples were processed for immunohistochemistry. The results showed circadian variation of VEGF expression in hepatectomized mice (control group) and hepatectomized-tumor-bearing mice. The maximum value of VEGF expression was found at 16:00/30 h of day/hour post-hepatectomy (HD/HPH) in tumor-bearing young mice, and at 20:00/34 HD/HPH in the controls. In adult mice the maximum values of VEGF expression were at 16:00/30 HD/HPH in tumor-bearing mice, and at 08:00/46 HD/ HPH in the controls. Young tumor-bearing mice showed significantly higher mean values than the controls. In conclusion, the presence of the tumor in the animals induces modifications in the intensity and the temporal distribution of the circadian curves of VEGF expression.
format Articulo
Articulo
author Fernández Blanco, Ayelén
Andrini, Laura Beatriz
Errecalde, Ana Lía
Inda, Ana María
García, Marcela Nilda
author_facet Fernández Blanco, Ayelén
Andrini, Laura Beatriz
Errecalde, Ana Lía
Inda, Ana María
García, Marcela Nilda
author_sort Fernández Blanco, Ayelén
title Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_short Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_full Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_fullStr Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_full_unstemmed Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_sort circadian rhythm of vegf expression in the liver of hepatectomized-tumor-bearing adult and young mice
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/103324
work_keys_str_mv AT fernandezblancoayelen circadianrhythmofvegfexpressionintheliverofhepatectomizedtumorbearingadultandyoungmice
AT andrinilaurabeatriz circadianrhythmofvegfexpressionintheliverofhepatectomizedtumorbearingadultandyoungmice
AT errecaldeanalia circadianrhythmofvegfexpressionintheliverofhepatectomizedtumorbearingadultandyoungmice
AT indaanamaria circadianrhythmofvegfexpressionintheliverofhepatectomizedtumorbearingadultandyoungmice
AT garciamarcelanilda circadianrhythmofvegfexpressionintheliverofhepatectomizedtumorbearingadultandyoungmice
bdutipo_str Repositorios
_version_ 1764820441797492738

Ejemplares similares