Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture

The oxovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H<sub>2</sub>O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell pro...

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Autores principales: León, Ignacio Esteban, Etcheverry, Susana Beatriz, Parajón Costa, Beatriz Susana, Baran, Enrique José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/102418
https://ri.conicet.gov.ar/11336/14478
https://www.jmcs.org.mx/index.php/jmcs/article/view/204
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-102418
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
spellingShingle Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
León, Ignacio Esteban
Etcheverry, Susana Beatriz
Parajón Costa, Beatriz Susana
Baran, Enrique José
Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
topic_facet Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
description The oxovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H<sub>2</sub>O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H<sub>2</sub>O can be considered as a good candidate to be further investigated in relation to cancer treatment.
format Articulo
Articulo
author León, Ignacio Esteban
Etcheverry, Susana Beatriz
Parajón Costa, Beatriz Susana
Baran, Enrique José
author_facet León, Ignacio Esteban
Etcheverry, Susana Beatriz
Parajón Costa, Beatriz Susana
Baran, Enrique José
author_sort León, Ignacio Esteban
title Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_short Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_full Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_fullStr Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_full_unstemmed Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_sort spectroscopic characterization of an oxovanadium(iv) complex of oxodiacetic acid and 2,2’-bipyridine : bioactivity on osteoblast-like cells in culture
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/102418
https://ri.conicet.gov.ar/11336/14478
https://www.jmcs.org.mx/index.php/jmcs/article/view/204
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