AGEs and Bone Ageing in Diabetes Mellitus

Type 1 and type 2 Diabetes mellitus are associated with a decrease in bone quality that leads to an increase in low-stress fractures, a condition called diabetic osteopathy. A growing body of evidence strongly indicates that one of the main pathological mechanisms of diabetic osteopathy is an excess...

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Detalles Bibliográficos
Autores principales:	McCarthy, Antonio Desmond, Molinuevo, María Silvina, Cortizo, Ana María
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2013
Materias:	Biología Ciencias Médicas Diabetes Mellitus Advanced glycation end products Osteoporosis Receptor for ages Metformin Strontium ranelate Alendronate Receptor for AGEs
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/101872 https://ri.conicet.gov.ar/11336/23677 https://www.longdom.org/abstract/ages-and-bone-ageing-in-diabetes-mellitus-26995.html https://www.longdom.org/open-access/ages-and-bone-ageing-in-diabetes-mellitus-2155-6156.1000276.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Biología Ciencias Médicas Diabetes Mellitus Advanced glycation end products Osteoporosis Receptor for ages Metformin Strontium ranelate Alendronate Receptor for AGEs
spellingShingle	Biología Ciencias Médicas Diabetes Mellitus Advanced glycation end products Osteoporosis Receptor for ages Metformin Strontium ranelate Alendronate Receptor for AGEs McCarthy, Antonio Desmond Molinuevo, María Silvina Cortizo, Ana María AGEs and Bone Ageing in Diabetes Mellitus
topic_facet	Biología Ciencias Médicas Diabetes Mellitus Advanced glycation end products Osteoporosis Receptor for ages Metformin Strontium ranelate Alendronate Receptor for AGEs
description	Type 1 and type 2 Diabetes mellitus are associated with a decrease in bone quality that leads to an increase in low-stress fractures, a condition called diabetic osteopathy. A growing body of evidence strongly indicates that one of the main pathological mechanisms of diabetic osteopathy is an excess accumulation of advanced glycation end products (AGEs) on collagen of bone extracellular matrix. This accumulation increases exponentially during ageing, and is further increased in conditions of substrate carbonyl stress such as chronically uncompensated Diabetes mellitus. AGEs can form covalent crosslinks throughout collagen fibrils, progressively increasing bone fragility and decreasing bone post-yield strain and energy, fracture resistance and toughness. In addition, bone marrow mesenchymal cells, osteoblasts and osteoclasts express receptors such as RAGE that can bind AGEs with high affinity, altering normal cellular homeostasis. Binding of AGEs by RAGE diminishes the osteogenic potential of mesenchymal cells, inhibits osteoblastic bone-forming capacity and induces a long-term decrease in osteoclastic recruitment and bone-resorbing activity. Altogether, these cellular effects of AGEs depress bone turnover, and thus induce an even greater accumulation of AGEs. Recent in vivo, ex vivo and in vitro evidence indicates that anti-diabetic and anti-osteoporotic treatment may prevent the deleterious effects of AGEs on bone cells, providing alternative options for the pharmacological treatment of diabetic osteopathy.
format	Articulo Articulo
author	McCarthy, Antonio Desmond Molinuevo, María Silvina Cortizo, Ana María
author_facet	McCarthy, Antonio Desmond Molinuevo, María Silvina Cortizo, Ana María
author_sort	McCarthy, Antonio Desmond
title	AGEs and Bone Ageing in Diabetes Mellitus
title_short	AGEs and Bone Ageing in Diabetes Mellitus
title_full	AGEs and Bone Ageing in Diabetes Mellitus
title_fullStr	AGEs and Bone Ageing in Diabetes Mellitus
title_full_unstemmed	AGEs and Bone Ageing in Diabetes Mellitus
title_sort	ages and bone ageing in diabetes mellitus
publishDate	2013
url	http://sedici.unlp.edu.ar/handle/10915/101872 https://ri.conicet.gov.ar/11336/23677 https://www.longdom.org/abstract/ages-and-bone-ageing-in-diabetes-mellitus-26995.html https://www.longdom.org/open-access/ages-and-bone-ageing-in-diabetes-mellitus-2155-6156.1000276.pdf
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bdutipo_str	Repositorios
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AGEs and Bone Ageing in Diabetes Mellitus

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