Circadian rhythms of proliferation events in two mouse carcinomas

We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h...

Descripción completa

Detalles Bibliográficos
Autores principales: García, Marcela Nilda, Andrini, Laura Beatriz, Martínez, Marina, Inda, Ana María, Palma, María Belén, Miriuka, Santiago Gabriel, Errecalde, Ana Lía
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Carcinoma
Circadian rhythms
DNA synthesis
Mice
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/101564
https://ri.conicet.gov.ar/11336/38465
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-101564
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Carcinoma
Circadian rhythms
DNA synthesis
Mice
spellingShingle Ciencias Médicas
Carcinoma
Circadian rhythms
DNA synthesis
Mice
García, Marcela Nilda
Andrini, Laura Beatriz
Martínez, Marina
Inda, Ana María
Palma, María Belén
Miriuka, Santiago Gabriel
Errecalde, Ana Lía
Circadian rhythms of proliferation events in two mouse carcinomas
topic_facet Ciencias Médicas
Carcinoma
Circadian rhythms
DNA synthesis
Mice
description We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h shows significative differences, the TN60 has higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.
format Articulo
Preprint
author García, Marcela Nilda
Andrini, Laura Beatriz
Martínez, Marina
Inda, Ana María
Palma, María Belén
Miriuka, Santiago Gabriel
Errecalde, Ana Lía
author_facet García, Marcela Nilda
Andrini, Laura Beatriz
Martínez, Marina
Inda, Ana María
Palma, María Belén
Miriuka, Santiago Gabriel
Errecalde, Ana Lía
author_sort García, Marcela Nilda
title Circadian rhythms of proliferation events in two mouse carcinomas
title_short Circadian rhythms of proliferation events in two mouse carcinomas
title_full Circadian rhythms of proliferation events in two mouse carcinomas
title_fullStr Circadian rhythms of proliferation events in two mouse carcinomas
title_full_unstemmed Circadian rhythms of proliferation events in two mouse carcinomas
title_sort circadian rhythms of proliferation events in two mouse carcinomas
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/101564
https://ri.conicet.gov.ar/11336/38465
work_keys_str_mv AT garciamarcelanilda circadianrhythmsofproliferationeventsintwomousecarcinomas
AT andrinilaurabeatriz circadianrhythmsofproliferationeventsintwomousecarcinomas
AT martinezmarina circadianrhythmsofproliferationeventsintwomousecarcinomas
AT indaanamaria circadianrhythmsofproliferationeventsintwomousecarcinomas
AT palmamariabelen circadianrhythmsofproliferationeventsintwomousecarcinomas
AT miriukasantiagogabriel circadianrhythmsofproliferationeventsintwomousecarcinomas
AT errecaldeanalia circadianrhythmsofproliferationeventsintwomousecarcinomas
bdutipo_str Repositorios
_version_ 1764820442686685184

Ejemplares similares