Adverse social determinats and risk for congenital anomalies

Introduction: Different studies have related familiar and regional adverse social conditions to perinatal outcome (neonatal mortality, low birth weight and prematurity); however, few studies have studied the effect of poverty on congenital anomalies. Objective:To assess the hazard ratio of 25 conge...

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Autores principales:	Pawluk, Mariela Soledad, Campaña, Hebe, Gili, Juan Antonio, Comas, Belén, Giménez, Lucas Gabriel, Villalba, María Inés, Scala, Sandra C., Poletta, Fernando Adrián, López Camelo, Jorge Santiago
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2014
Materias:	Ciencias Médicas Anomalías Congénitas Inequidad Labio Leporino Comunicación interventricular Congenital anomalies Iinequities Cleft lip Ventricular septal defect
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/101463 https://ri.conicet.gov.ar/11336/35118 http://www.sap.org.ar/docs/publicaciones/archivosarg/2014/v112n3a04.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-101463
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Anomalías Congénitas Inequidad Labio Leporino Comunicación interventricular Congenital anomalies Iinequities Cleft lip Ventricular septal defect
spellingShingle	Ciencias Médicas Anomalías Congénitas Inequidad Labio Leporino Comunicación interventricular Congenital anomalies Iinequities Cleft lip Ventricular septal defect Pawluk, Mariela Soledad Campaña, Hebe Gili, Juan Antonio Comas, Belén Giménez, Lucas Gabriel Villalba, María Inés Scala, Sandra C. Poletta, Fernando Adrián López Camelo, Jorge Santiago Adverse social determinats and risk for congenital anomalies
topic_facet	Ciencias Médicas Anomalías Congénitas Inequidad Labio Leporino Comunicación interventricular Congenital anomalies Iinequities Cleft lip Ventricular septal defect
description	Introduction: Different studies have related familiar and regional adverse social conditions to perinatal outcome (neonatal mortality, low birth weight and prematurity); however, few studies have studied the effect of poverty on congenital anomalies. Objective:To assess the hazard ratio of 25 congenital anomalies and adverse social determinants as per the socioeconomic level of families and regions. Population and methods: Exploratory, casecontrol study using data from the Latin-American Collaborative Study of Congenital Malformations (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas, ECLAMC). The sample consisted of 3786 live newborn infants with a single malformation and 13 344 controls selected among 546 129 births occurred in 39 hospitals from Argentina in the 1992- 2001 period. Both direct and indirect (residence) risks (OR) were estimated, together with the interaction between the individual and residential socioeconomic levels for each of the 25 congenital anomalies. Results: Cleft lip with/without cleft palate (OR= 1.43) and ventricular septal defect (OR= 1.38) showed a significantly higher risk in the lower socioeconomic level. Low socioeconomic levels were significantly associated with a higher frequency of parental sibship (blood relationship), native descent, maternal age younger than 19 years old, more than four pregnancies, a low number of antenatal care visits, and residence in deprived regions. Conclusion: Cleft lip with/without cleft palate and ventricular septal defects were significantly associated with a lower socioeconomic level. Lack of family planning and antenatal care, and exposure to environmental or teratogenic agents may account for these findings.
format	Articulo Articulo
author	Pawluk, Mariela Soledad Campaña, Hebe Gili, Juan Antonio Comas, Belén Giménez, Lucas Gabriel Villalba, María Inés Scala, Sandra C. Poletta, Fernando Adrián López Camelo, Jorge Santiago
author_facet	Pawluk, Mariela Soledad Campaña, Hebe Gili, Juan Antonio Comas, Belén Giménez, Lucas Gabriel Villalba, María Inés Scala, Sandra C. Poletta, Fernando Adrián López Camelo, Jorge Santiago
author_sort	Pawluk, Mariela Soledad
title	Adverse social determinats and risk for congenital anomalies
title_short	Adverse social determinats and risk for congenital anomalies
title_full	Adverse social determinats and risk for congenital anomalies
title_fullStr	Adverse social determinats and risk for congenital anomalies
title_full_unstemmed	Adverse social determinats and risk for congenital anomalies
title_sort	adverse social determinats and risk for congenital anomalies
publishDate	2014
url	http://sedici.unlp.edu.ar/handle/10915/101463 https://ri.conicet.gov.ar/11336/35118 http://www.sap.org.ar/docs/publicaciones/archivosarg/2014/v112n3a04.pdf
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Adverse social determinats and risk for congenital anomalies

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