Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration

Growing body of evidence suggests that mitochondrial dysfunctions and resultant oxidative stress are likely responsible for many neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Aldehyde dehydrogenase (ALDH) superfamily plays a crucial role in se...

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Detalles Bibliográficos
Autores principales: Deza Ponzio, Romina, Herrera,Macarena Lorena, Bellini, María José, Virgolini, Miriam Beatriz, Hereñú, Claudia Beatriz
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
Materias:
Bioquímica
Aldehyde dehydrogenase 2
Alzheimer's disease
Mitochondrial dysfunction
Oxidative stress
Parkinson's disease
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/101038
https://ri.conicet.gov.ar/11336/89633
https://linkinghub.elsevier.com/retrieve/pii/S0161813X18302109
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-101038
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Aldehyde dehydrogenase 2
Alzheimer's disease
Mitochondrial dysfunction
Oxidative stress
Parkinson's disease
spellingShingle Bioquímica
Aldehyde dehydrogenase 2
Alzheimer's disease
Mitochondrial dysfunction
Oxidative stress
Parkinson's disease
Deza Ponzio, Romina
Herrera,Macarena Lorena
Bellini, María José
Virgolini, Miriam Beatriz
Hereñú, Claudia Beatriz
Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
topic_facet Bioquímica
Aldehyde dehydrogenase 2
Alzheimer's disease
Mitochondrial dysfunction
Oxidative stress
Parkinson's disease
description Growing body of evidence suggests that mitochondrial dysfunctions and resultant oxidative stress are likely responsible for many neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Aldehyde dehydrogenase (ALDH) superfamily plays a crucial role in several biological processes including development and detoxification pathways in the organism. In particular, ALDH2 is crucial in the oxidative metabolism of toxic aldehydes in the brain, such as catecholaminergic metabolites (DOPAL and DOPEGAL) and the principal product of lipid peroxidation process 4-HNE. This review aims to deepen the current knowledge regarding to ALDH2 function and its relation with brain-damaging processes that increase the risk to develop neurodegenerative disorders. We focused on relevant literature of what is currently known at molecular and cellular levels in experimental models of these pathologies. The understanding of ALDH2 contributions could be a potential target in new therapeutic approaches for PD and AD due to its crucial role in mitochondrial normal function maintenance that protects against neurotoxicity.
format Articulo
Preprint
author Deza Ponzio, Romina
Herrera,Macarena Lorena
Bellini, María José
Virgolini, Miriam Beatriz
Hereñú, Claudia Beatriz
author_facet Deza Ponzio, Romina
Herrera,Macarena Lorena
Bellini, María José
Virgolini, Miriam Beatriz
Hereñú, Claudia Beatriz
author_sort Deza Ponzio, Romina
title Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
title_short Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
title_full Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
title_fullStr Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
title_full_unstemmed Aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
title_sort aldehyde dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/101038
https://ri.conicet.gov.ar/11336/89633
https://linkinghub.elsevier.com/retrieve/pii/S0161813X18302109
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