Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and gui...
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Autores principales: | , , , |
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Formato: | Articulo Revision |
Lenguaje: | Inglés |
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2017
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/101003 https://ri.conicet.gov.ar/11336/42000 http://pmr.safisiol.org.ar/archive/id/95 |
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I19-R120-10915-101003 |
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institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Médicas Calorimetry Cardiac stunning Sarcoplasmic reticulum Mitochondria Calcium |
spellingShingle |
Ciencias Médicas Calorimetry Cardiac stunning Sarcoplasmic reticulum Mitochondria Calcium Consolini, Alicia Elvira Ragone, María Inés Colareda, Germán Andrés Bonazzola, Patricia Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
topic_facet |
Ciencias Médicas Calorimetry Cardiac stunning Sarcoplasmic reticulum Mitochondria Calcium |
description |
This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences. |
format |
Articulo Revision |
author |
Consolini, Alicia Elvira Ragone, María Inés Colareda, Germán Andrés Bonazzola, Patricia |
author_facet |
Consolini, Alicia Elvira Ragone, María Inés Colareda, Germán Andrés Bonazzola, Patricia |
author_sort |
Consolini, Alicia Elvira |
title |
Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
title_short |
Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
title_full |
Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
title_fullStr |
Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
title_full_unstemmed |
Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
title_sort |
calorimetry of isolated hearts (ii) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion |
publishDate |
2017 |
url |
http://sedici.unlp.edu.ar/handle/10915/101003 https://ri.conicet.gov.ar/11336/42000 http://pmr.safisiol.org.ar/archive/id/95 |
work_keys_str_mv |
AT consolinialiciaelvira calorimetryofisolatedheartsiienergeticofca2homeostasisindifferentanimalmodelsandduringischemiareperfusion AT ragonemariaines calorimetryofisolatedheartsiienergeticofca2homeostasisindifferentanimalmodelsandduringischemiareperfusion AT colaredagermanandres calorimetryofisolatedheartsiienergeticofca2homeostasisindifferentanimalmodelsandduringischemiareperfusion AT bonazzolapatricia calorimetryofisolatedheartsiienergeticofca2homeostasisindifferentanimalmodelsandduringischemiareperfusion |
bdutipo_str |
Repositorios |
_version_ |
1764820440412323842 |