Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, howeve...

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Autores principales: Grumelli, Sandra, Islan, Germán Abel, Castro, Guillermo Raúl
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Médicas
Cystic fibrosis
CFTR-deficiency
CF-immune response
Antibiotic therapies
Microbioma maintenance
Gene therapy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/100520
https://ri.conicet.gov.ar/11336/49503
http://oatext.com/Consequences-of-cystic-fibrosis-transmembrane-regulator-mutations-on-inflammatory-cells.php
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-100520
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Cystic fibrosis
CFTR-deficiency
CF-immune response
Antibiotic therapies
Microbioma maintenance
Gene therapy
spellingShingle Ciencias Médicas
Cystic fibrosis
CFTR-deficiency
CF-immune response
Antibiotic therapies
Microbioma maintenance
Gene therapy
Grumelli, Sandra
Islan, Germán Abel
Castro, Guillermo Raúl
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
topic_facet Ciencias Médicas
Cystic fibrosis
CFTR-deficiency
CF-immune response
Antibiotic therapies
Microbioma maintenance
Gene therapy
description Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date.
format Articulo
Revision
author Grumelli, Sandra
Islan, Germán Abel
Castro, Guillermo Raúl
author_facet Grumelli, Sandra
Islan, Germán Abel
Castro, Guillermo Raúl
author_sort Grumelli, Sandra
title Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
title_short Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
title_full Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
title_fullStr Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
title_full_unstemmed Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
title_sort consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/100520
https://ri.conicet.gov.ar/11336/49503
http://oatext.com/Consequences-of-cystic-fibrosis-transmembrane-regulator-mutations-on-inflammatory-cells.php
work_keys_str_mv AT grumellisandra consequencesofcysticfibrosistransmembraneregulatormutationsoninflammatorycells
AT islangermanabel consequencesofcysticfibrosistransmembraneregulatormutationsoninflammatorycells
AT castroguillermoraul consequencesofcysticfibrosistransmembraneregulatormutationsoninflammatorycells
bdutipo_str Repositorios
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