Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP

Although PTHrP is implicated in several cancers, its role in chemoresistance is not fully elucidated. We found that in CRC cells, PTHrP exerts proliferative and protective effects and induces cell migration. The aim of this work was to further study the effects of PTHrP in CRC cells. Herein we evide...

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Detalles Bibliográficos
Autores principales: Martín, María Julia, Gigola, Graciela, Zwenger, Ariel, Carriquiriborde, Martín, Gentil, Florencia, Gentili, Claudia Rosana
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Chemoresistance
Colorectal cancer
Mitogenic signaling
Molecular mechanisms
Pthrp
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/100081
https://ri.conicet.gov.ar/11336/91603
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-100081
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Chemoresistance
Colorectal cancer
Mitogenic signaling
Molecular mechanisms
Pthrp
spellingShingle Ciencias Médicas
Chemoresistance
Colorectal cancer
Mitogenic signaling
Molecular mechanisms
Pthrp
Martín, María Julia
Gigola, Graciela
Zwenger, Ariel
Carriquiriborde, Martín
Gentil, Florencia
Gentili, Claudia Rosana
Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
topic_facet Ciencias Médicas
Chemoresistance
Colorectal cancer
Mitogenic signaling
Molecular mechanisms
Pthrp
description Although PTHrP is implicated in several cancers, its role in chemoresistance is not fully elucidated. We found that in CRC cells, PTHrP exerts proliferative and protective effects and induces cell migration. The aim of this work was to further study the effects of PTHrP in CRC cells. Herein we evidenced, for the first time, that PTHrP induces resistance to CPT-11 in Caco-2 and HCT116 cells; although both cell lines responded to the drug through different molecular mechanisms, the chemoresistance by PTHrP in these models is mediated through ERK, which in turn is activated by PCK, Src and Akt. Moreover, continue administration of PTHrP in nude mice xenografts increased the protein levels of this MAPK and of other markers related to tumorigenic events. The understanding of the molecular mechanisms leading to ERK 1/2 activation and the study of ERK targets may facilitate the development of new therapeutic strategies for CRC treatment.
format Articulo
Preprint
author Martín, María Julia
Gigola, Graciela
Zwenger, Ariel
Carriquiriborde, Martín
Gentil, Florencia
Gentili, Claudia Rosana
author_facet Martín, María Julia
Gigola, Graciela
Zwenger, Ariel
Carriquiriborde, Martín
Gentil, Florencia
Gentili, Claudia Rosana
author_sort Martín, María Julia
title Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
title_short Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
title_full Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
title_fullStr Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
title_full_unstemmed Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
title_sort potential therapeutic targets for growth arrest of colorectal cancer cells exposed to pthrp
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/100081
https://ri.conicet.gov.ar/11336/91603
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