Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces

A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup>...

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Detalles Bibliográficos
Autor principal: Perez Enriquez, Darlin J.
Otros Autores: Dell'arciprete, María L., Dittler, María Laura, Miñan, Alejandro, Prieto, Eduardo, Gonzalez, Mónica C.
Formato: Artículo
Lenguaje:Inglés
Materias:
Calcium phosphate nanoshells
Ca<sup>+2</sup>activation
Surface interaction
Carboxyl group
Drug release
Bacterial susceptibility
Acceso en línea:https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf
10.1039/C9NJ06414A
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca BIBHUMA (FAHCE-UNLP) de Universidad Nacional de La Plata
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100 |a Perez Enriquez, Darlin J.  |u Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) 
700 |a Dell'arciprete, María L.  |u Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) 
700 |a Dittler, María Laura  |u Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) 
700 |a Miñan, Alejandro  |u Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) 
700 |a Prieto, Eduardo  |u Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) 
700 |a Gonzalez, Mónica C.  |u Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) 
245 1 0 |a Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces 
041 7 |2 ISO 639-1  |a en 
300 |a  p.7541-7551 
520 3 |a A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5&&num;174; bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed. 
653 |a Calcium phosphate nanoshells 
653 |a Ca<sup>+2</sup>activation 
653 |a Surface interaction 
653 |a Carboxyl group 
653 |a Drug release 
653 |a Bacterial susceptibility 
856 4 0 |u https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf 
856 |u 10.1039/C9NJ06414A 
952 |u https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf  |a MEMORIA ACADEMICA  |b MEMORIA ACADEMICA 
773 0 |7 nnas  |t New Journal of Chemistry.   |g Vol. 44 No. 18 (2020),7541-7551  |v 44  |l 18  |q 7541-7551  |d Reino Unido : Royal Society of Chemistry, 2020  |x ISSN 1369-9261 
542 1 |f Esta obra está bajo una licencia Creative Commons Atribución-NoComercial-CompartirIgual 4.0 Internacional  |u https://creativecommons.org/licenses/by-nc-sa/4.0/ 

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