nonhuman 36 article 32 controlled study 32 Heme metabolism 30 animal experiment 28 enzyme activity 28 mouse 28 5 aminolevulinate synthase 26 male 26 Animals 24 animal model 24 Mice 20 animal tissue 20 heme oxygenase 20 priority journal 20 5-Aminolevulinate Synthetase 18 Liver 18 heme 18 Heme 16 Male 16 Oxidative Stress 16 isoflurane 16 Animalia 14 oxidative stress 14 acute intermittent porphyria 12 glutathione 12 porphobilinogen deaminase 12 Heme Oxygenase (Decyclizing) 10 Isoflurane 10 Oxidative stress 10