article nonhuman 178 controlled study 150 priority journal 148 Heme 124 heme 120 Animals 118 male 98 animal experiment 94 Male 92 Mice 92 mouse 92 5 aminolevulinate synthase 86 enzyme activity 86 5-Aminolevulinate Synthetase 76 animal tissue 76 Liver 68 Porphyrins 66 metabolism 64 animal model 62 rat 54 Humans 52 heme synthesis 52 human 52 porphyrin 52 Animal 46 Support, Non-U.S. Gov't 46 oxidative stress 46 Rats 44 molecular dynamics 44