animal experiment enzyme activity nonhuman 205 priority journal controlled study 186 article 159 Animals 135 animal tissue 126 mouse 103 animal model 93 male 93 Mice 68 protein expression 66 rat 66 female 64 Male 63 animal cell 62 unclassified drug 54 metabolism 53 Female 50 Rats 50 animal 42 Animalia 36 Article 36 Liver 35 signal transduction 32 enzyme inhibition 29 Mice, Inbred BALB C 28 Humans 25 Rats, Wistar 24