enzyme activity metabolism nonhuman controlled study 140 Animals 124 Article 114 animal 114 priority journal 106 article 91 animal experiment 81 enzymology 70 unclassified drug 66 animal tissue 63 mouse 57 physiology 51 Mice 47 protein expression 45 chemistry 44 oxidative stress 42 male 41 genetics 40 animal cell 38 drug effects 36 Water Pollutants, Chemical 34 catalase 34 drug effect 33 superoxide dismutase 32 signal transduction 31 female 30 water pollutant 30