enzyme activity metabolism nonhuman 207 controlled study 173 Animals 149 animal 139 Article 136 priority journal 135 article 131 enzymology 92 unclassified drug 85 animal experiment 81 human 78 physiology 78 genetics 70 Humans 69 chemistry 66 mouse 64 animal tissue 63 signal transduction 62 protein expression 59 Mice 54 oxidative stress 51 drug effects 50 male 47 female 46 drug effect 41 superoxide dismutase 41 Western blotting 39 animal cell 38