controlled study protein expression upregulation nonhuman 74 Animals 64 human 64 priority journal 64 article 57 animal experiment 55 Humans 54 Article 52 human cell 50 metabolism 49 female 47 animal cell 46 mouse 45 Female 41 animal tissue 41 Mice 39 male 39 animal model 37 animal 35 apoptosis 31 down regulation 31 genetics 31 messenger RNA 31 unclassified drug 31 cell proliferation 29 signal transduction 28 Male 27