animal cell controlled study nonhuman signal transduction priority journal 215 Animals 205 article 188 mouse 142 Mice 124 Signal Transduction 107 protein expression 99 animal 94 animal experiment 92 animal tissue 89 metabolism 88 female 84 human 81 Humans 80 unclassified drug 78 animal model 68 Female 65 cell proliferation 62 rat 62 human cell 61 male 56 enzyme activation 55 Article 54 Rats 52 messenger RNA 50 genetics 46