article nonhuman unclassified drug controlled study 924 priority journal 854 Animals 731 animal cell 512 mouse 282 Humans 273 Mice 273 animal experiment 270 human 246 protein expression 233 animal tissue 224 enzyme activity 213 rat 192 Rats 178 male 168 Male 167 Female 159 female 159 human cell 158 metabolism 156 animal model 150 animal 143 protein function 140 Trypanosoma cruzi 138 drug structure 137 in vitro study 131 Animalia 129