Amino Acid Sequence Animals Aves Binding Sites Bisphosphonates Carbon Chagas disease Chagas' disease Diseases Enzymes Farnesyl pyrophosphate synthase Geranyltranstransferase Homology modeling Hydrogen bonds Models, Molecular Molecular Sequence Data Molecular Structure Molecular dynamics Sequence Homology, Amino Acid Structural Homology, Protein Structure-Activity Relationship Trypanosoma cruzi article bisphosphonic acid derivative chemical binding chemical model chemical structure dimethylallylpyrophosphate enzyme active site enzyme activity