animal tissue article controlled study enzyme activity nonhuman Animals 155 priority journal 142 animal experiment 130 male 93 rat 86 mouse 70 Male 66 Rats 66 Mice 62 animal model 61 female 55 Female 52 Animalia 47 animal cell 47 protein expression 47 Liver 44 unclassified drug 37 enzyme inhibition 33 Rats, Wistar 30 signal transduction 30 Rats, Sprague-Dawley 26 oxidative stress 26 catalase 24 5 aminolevulinate synthase 23 lipid peroxidation 22