Animals animal cell animal tissue controlled study nonhuman priority journal 304 article 285 animal experiment 268 mouse 197 Mice 193 female 188 animal model 177 male 164 Female 163 animal 150 protein expression 145 Male 138 metabolism 113 rat 113 Article 104 Rats 103 unclassified drug 94 signal transduction 81 Humans 76 cell proliferation 73 messenger RNA 73 physiology 66 human 65 in vitro study 65 in vivo study 63